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锂离子通过培养的小鼠神经母细胞瘤细胞的钠通道进入：一项生化研究。

Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: a biochemical study.

作者信息

Richelson E

出版信息

Science. 1977 May 27;196(4293):1001-2. doi: 10.1126/science.860126.

DOI:10.1126/science.860126
PMID:860126
Abstract

Lithium ion entry at low concentrations (1 to 5 mM) into an electrically active adrenergic clone of mouse neuroblastoma cells was stimulated by veratridine; and this stimulation was blocked by tetrodotoxin, These data provide biochemical evidence that lithium ions enter by way of the sodium channel which may be a major pathway for entry of this ion into electrically active cells.

摘要

在低浓度（1至5毫摩尔）下，藜芦定可刺激锂离子进入电活性的小鼠神经母细胞瘤细胞肾上腺素能克隆；而这种刺激可被河豚毒素阻断。这些数据提供了生化证据，表明锂离子通过钠通道进入细胞，这可能是该离子进入电活性细胞的主要途径。

相似文献

1
Lithium ion entry through the sodium channel of cultured mouse neuroblastoma cells: a biochemical study.锂离子通过培养的小鼠神经母细胞瘤细胞的钠通道进入：一项生化研究。
Science. 1977 May 27;196(4293):1001-2. doi: 10.1126/science.860126.
2
Lithium ion uptake associated with the stimulation of action potential ionophores of cultured human neuroblastoma cells.锂离子摄取与培养的人神经母细胞瘤细胞动作电位离子载体的刺激相关。
Life Sci. 1979 Sep 11;25(11):957-67. doi: 10.1016/0024-3205(79)90501-0.
3
Transport pathways for lithium ions in neuroblastoma x glioma hybrid cells at 'therapeutic' concentrations of Li+.在“治疗性”锂离子浓度下，神经母细胞瘤x胶质瘤杂交细胞中锂离子的转运途径。
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4
Pharmacological and electrophysiological characterization of lithium ion flux through the action potential sodium channel in neuroblastoma X glioma hybrid cells.神经母细胞瘤X胶质瘤杂交细胞中锂离子通过动作电位钠通道的通量的药理学和电生理学特征
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Sodium uptake associated with activation of action potential ionophores of cultured neuroblastoma and muscle cells.与培养的神经母细胞瘤和肌肉细胞动作电位离子载体激活相关的钠摄取。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3759-63. doi: 10.1073/pnas.70.12.3759.
6
Sodium-channels in non-excitable glioma cells, shown by the influence of veratridine, scorpion toxin, and tetrodotoxin on membrane potential and on ion transport.藜芦碱、蝎毒素和河豚毒素对膜电位及离子转运的影响表明，非兴奋性胶质瘤细胞中存在钠通道。
Pflugers Arch. 1983 Jun 1;397(4):260-4. doi: 10.1007/BF00580258.
7
Potentiation by a sodium channel activator of effects of lithium ion on cyclic AMP, cyclic GMP and inositol phosphates.
Neuropharmacology. 1991 May;30(5):497-500. doi: 10.1016/0028-3908(91)90012-z.
8
Indirect ultrastructural evidence for lithium uptake by cultured rat cerebral cells through the sodium channel.培养的大鼠脑细胞通过钠通道摄取锂的间接超微结构证据。
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Cooperative activation of action potential Na+ ionophore by neurotoxins.神经毒素对动作电位钠离子载体的协同激活作用。
Proc Natl Acad Sci U S A. 1975 May;72(5):1782-6. doi: 10.1073/pnas.72.5.1782.
10
Membrane excitability expressed in human neuroblastoma cell hybrids.人类神经母细胞瘤细胞杂交体中表达的膜兴奋性。
FEBS Lett. 1988 Aug 15;236(1):39-42. doi: 10.1016/0014-5793(88)80281-3.

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Effects of lithium isotopes on sodium/lithium co-transport and calcium efflux through the sodium/calcium/lithium exchanger in mitochondria.锂同位素对线粒体中钠/锂共转运以及通过钠/钙/锂交换体的钙外流的影响。
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Search for lithium isotope effects in neuronal HT22 cells.
在神经元HT22细胞中寻找锂同位素效应。
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DNAzyme-Based Lithium-Selective Imaging Reveals Higher Lithium Accumulation in Bipolar Disorder Patient-Derived Neurons.基于脱氧核酶的锂选择性成像揭示双相情感障碍患者来源神经元中锂的积累更高。
ACS Cent Sci. 2021 Nov 24;7(11):1809-1820. doi: 10.1021/acscentsci.1c00843. Epub 2021 Nov 3.
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Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7.藜芦碱可调节人电压门控钠离子通道 Nav1.7 的门控。
Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724. doi: 10.1038/s41401-018-0065-z. Epub 2018 Jun 27.
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Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology.迈向对锂在基础生物学中的作用及其对应用生物学意义的统一理解。
J Membr Biol. 2017 Dec;250(6):587-604. doi: 10.1007/s00232-017-9998-2. Epub 2017 Nov 10.
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Sodium-dependent release of exogenous glycine from preloaded rat hippocampal synaptosomes.从预先加载的大鼠海马突触体中钠依赖性释放外源性甘氨酸。
J Neural Transm Gen Sect. 1993;93(3):167-79. doi: 10.1007/BF01244994.
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Steady-state distribution of lithium during cultivation of dissociated brain cells.离体脑细胞培养过程中锂的稳态分布
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Lithium pharmacokinetics: single-dose experiments and analysis using a physiological model.锂的药代动力学：单剂量实验及使用生理模型的分析
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A study of calcium compartments in rat brain cortex thin slices: effects of veratridine, lithium and of a mitochondrial uncoupler.大鼠大脑皮层薄片中钙区室的研究：藜芦定、锂及线粒体解偶联剂的作用
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