Synthesis of no-carrier-added L- and D-[1-11C]-DOPA.
作者信息
Bolster J M, Vaalburg W, Van Veen W, Van Dijk T, Van der Molen H D, Wynberg H, Woldring M G
出版信息
Int J Appl Radiat Isot. 1983 Dec;34(12):1650-2. doi: 10.1016/0020-708x(83)90019-4.
PMID:6421752
Abstract
No-carrier-added DL-[1-11C]-DOPA has been synthesized by carboxylation of an alpha-lithioisocyanide with a radiochemical yield of up to 15% without correction for decay. The total synthesis time is 30 min. The resolution of the D- and L-isomers was accomplished within 16 min by HPLC using a chiral stationary phase and a phosphate buffer of pH 4.5 as eluent.
摘要
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