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Isolation of Bacillus subtilis mutants pleiotropically insensitive to glucose catabolite repression.对葡萄糖分解代谢阻遏表现出多效性不敏感的枯草芽孢杆菌突变体的分离。
J Bacteriol. 1984 Mar;157(3):942-4. doi: 10.1128/jb.157.3.942-944.1984.
2
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.2-酮戊二酸与枯草芽孢杆菌中乌头酸酶和组氨酸酶形成的调节
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3
Comparative studies on induction of sporulation and synthesis of inducible enzymes in Bacillus subtilis.枯草芽孢杆菌中孢子形成诱导及诱导酶合成的比较研究。
J Bacteriol. 1974 Dec;120(3):1102-8. doi: 10.1128/jb.120.3.1102-1108.1974.
4
Modulation of Bacillus subtilis catabolite repression by transition state regulatory protein AbrB.过渡态调节蛋白AbrB对枯草芽孢杆菌分解代谢物阻遏的调控
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Bacillus subtilis glutamine synthetase mutants pleiotropically altered in glucose catabolite repression.枯草芽孢杆菌谷氨酰胺合成酶突变体在葡萄糖分解代谢阻遏中发生多效性改变。
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Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis.ptsH基因突变导致磷酸转移酶系统的磷酸载体蛋白HPr失去蛋白激酶催化的磷酸化作用，这使得枯草芽孢杆菌的几个分解代谢基因具有抗分解代谢物阻遏的特性。
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How phosphotransferase system-related protein phosphorylation regulates carbohydrate metabolism in bacteria.磷酸转移酶系统相关蛋白磷酸化如何调节细菌中的碳水化合物代谢。
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5
Activation of the Bacillus subtilis hut operon at the onset of stationary growth phase in nutrient sporulation medium results primarily from the relief of amino acid repression of histidine transport.在营养芽孢形成培养基中，枯草芽孢杆菌组氨酸操纵子在稳定生长期开始时的激活主要源于组氨酸转运的氨基酸阻遏作用的解除。
J Bacteriol. 1993 Jul;175(14):4282-9. doi: 10.1128/jb.175.14.4282-4289.1993.
6
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.2-酮戊二酸与枯草芽孢杆菌中乌头酸酶和组氨酸酶形成的调节
J Bacteriol. 1984 Apr;158(1):379-82. doi: 10.1128/jb.158.1.379-382.1984.
7
Early-blocked sporulation mutations alter expression of enzymes under carbon control in Bacillus subtilis.早期阻断芽孢形成的突变会改变枯草芽孢杆菌中受碳源调控的酶的表达。
Mol Gen Genet. 1988 May;212(2):271-80. doi: 10.1007/BF00334696.
8
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9
cis sequences involved in modulating expression of Bacillus licheniformis amyL in Bacillus subtilis: effect of sporulation mutations and catabolite repression resistance mutations on expression.参与调节枯草芽孢杆菌中地衣芽孢杆菌amyL表达的顺式作用序列：芽孢形成突变和分解代谢物阻遏抗性突变对表达的影响。
J Bacteriol. 1989 May;171(5):2443-50. doi: 10.1128/jb.171.5.2443-2450.1989.
10
Expression of the Bacillus subtilis xyl operon is repressed at the level of transcription and is induced by xylose.枯草芽孢杆菌木糖操纵子的表达在转录水平受到抑制，并由木糖诱导。
J Bacteriol. 1988 Jul;170(7):3102-9. doi: 10.1128/jb.170.7.3102-3109.1988.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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2
THE MOLECULAR BASIS OF HISTIDASE INDUCTION IN BACILLUS SUBTILIS.枯草芽孢杆菌中组氨酸酶诱导的分子基础
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Bacillus subtilis glutamine synthetase mutants pleiotropically altered in glucose catabolite repression.枯草芽孢杆菌谷氨酰胺合成酶突变体在葡萄糖分解代谢阻遏中发生多效性改变。
J Bacteriol. 1984 Feb;157(2):612-21. doi: 10.1128/jb.157.2.612-621.1984.
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Regulation of glutamate dehydrogenase in Bacillus subtilis.枯草芽孢杆菌中谷氨酸脱氢酶的调控
J Bacteriol. 1981 Dec;148(3):1002-5. doi: 10.1128/jb.148.3.1002-1005.1981.
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Symposium on bacterial spores: II. Genetics of sporulation in Bacillus subtilis Marburg.细菌芽孢研讨会：II. 枯草芽孢杆菌马堡株的芽孢形成遗传学
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7
Catabolite repression of aconitate hydratase in Bacillus subtilis.枯草芽孢杆菌中乌头酸水合酶的分解代谢物阻遏
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Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes.不同营养条件对三羧酸循环酶合成的影响。
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Inability of detect cyclic AMP in vegetative or sporulating cells or dormant spores of Bacillus megaterium.无法在巨大芽孢杆菌的营养细胞、产孢细胞或休眠孢子中检测到环磷酸腺苷。
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Construction of a kit of reference strains for rapid genetic mapping in Bacillus subtilis 168.构建用于枯草芽孢杆菌168快速基因定位的参考菌株试剂盒。
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对葡萄糖分解代谢阻遏表现出多效性不敏感的枯草芽孢杆菌突变体的分离。

Isolation of Bacillus subtilis mutants pleiotropically insensitive to glucose catabolite repression.

作者信息

Fisher S H, Magasanik B

出版信息

J Bacteriol. 1984 Mar;157(3):942-4. doi: 10.1128/jb.157.3.942-944.1984.

DOI:10.1128/jb.157.3.942-944.1984
PMID:6421803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC215352/
Abstract

A pleiotropic mutant of Bacillus subtilis was isolated which overproduced in the presence of glucose several enzymes whose synthesis is subject to glucose catabolite repression. Examination of intracellular metabolites suggested that the mutation may have resulted in a defect in glycolysis, increasing phosphoenolpyruvate and decreasing pyruvate, 2-ketoglutarate, and oxaloacetate.

摘要

分离出枯草芽孢杆菌的一个多效突变体，该突变体在葡萄糖存在的情况下过量产生几种其合成受葡萄糖分解代谢物阻遏的酶。对细胞内代谢物的检测表明，该突变可能导致糖酵解缺陷，增加磷酸烯醇丙酮酸并减少丙酮酸、2-酮戊二酸和草酰乙酸。