HPr在α-淀粉酶分解代谢阻遏中的意义
Significance of HPr in catabolite repression of alpha-amylase.
作者信息
Voskuil M I, Chambliss G H
机构信息
Department of Bacteriology, University of Wisconsin-Madison, 53706, USA.
出版信息
J Bacteriol. 1996 Dec;178(23):7014-5. doi: 10.1128/jb.178.23.7014-7015.1996.
Abstract
CcpA and HPr are presently the only two proteins implicated in Bacillus subtilis global carbon source catabolite repression, and the ptsH1 mutation in the gene for the HPr protein was reported to relieve catabolite repression of several genes. However, alpha-amylase synthesis by B. subtilis SA003 containing the ptsH1 mutation was repressed by glucose. Our results suggest HPr(Ser-P) may be involved in but is not required for catabolite repression of alpha-amylase, indicating that HPr(Ser-P) is not the sole signaling molecule for CcpA-mediated catabolite repression in B. subtilis.
摘要
目前，CcpA和HPr是仅有的两种与枯草芽孢杆菌全局碳源分解代谢物阻遏相关的蛋白质，据报道，HPr蛋白基因中的ptsH1突变可缓解几种基因的分解代谢物阻遏。然而，含有ptsH1突变的枯草芽孢杆菌SA003合成α-淀粉酶受到葡萄糖的抑制。我们的结果表明，HPr(Ser-P)可能参与但不是α-淀粉酶分解代谢物阻遏所必需的，这表明HPr(Ser-P)不是枯草芽孢杆菌中CcpA介导的分解代谢物阻遏的唯一信号分子。
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2
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