Bohles H, Segerer H, Fekl W
JPEN J Parenter Enteral Nutr. 1984 Jan-Feb;8(1):9-13. doi: 10.1177/014860718400800109.
The influence of intravenously administered L-carnitine on lipid- and nitrogen-metabolism was studied during total parenteral nutrition of piglets (mean weight 4077 g; n = 9). The infusion protocol was divided into three isocaloric and isonitrogenous 48-hr periods. Amino acids (3 g/kg day) were administered throughout all three periods: 140 cal/kg/day were given as nonprotein calories, consisting only of glucose during period 1; during periods 2 and 3, an amount of glucose calorically equivalent to 4 g fat/kg/day was substituted with a lipid emulsion, and L-carnitine (1.5 mg/kg/day) was added in period 3. Key parameters of fat- and nitrogen-metabolism were determined during the entire regime. Indirect calorimetry was performed and the respiratory quotient calculated during all three periods. The results demonstrate a more effective lipolysis and oxidation of fatty acids during L-carnitine supplementation. These changes produce an increased energy gain from exogenously administered fat and a distinct improvement in nitrogen balance.
在仔猪（平均体重4077克；n = 9）的全胃肠外营养期间，研究了静脉注射L-肉碱对脂质和氮代谢的影响。输注方案分为三个等热量和等氮量的48小时阶段。在所有三个阶段都给予氨基酸（3克/千克/天）：140千卡/千克/天作为非蛋白质热量，在第1阶段仅由葡萄糖提供；在第2和第3阶段，将热量相当于4克脂肪/千克/天的葡萄糖量替换为脂质乳剂，并在第3阶段添加L-肉碱（1.5毫克/千克/天）。在整个疗程中测定脂肪和氮代谢的关键参数。在所有三个阶段进行间接测热法并计算呼吸商。结果表明，补充L-肉碱期间脂肪酸的脂解和氧化更有效。这些变化使外源性给予的脂肪产生的能量增加，并使氮平衡有明显改善。
