Böhles H, Segerer H, Fekl W, Stehr K
Infusionsther Klin Ernahr. 1983 Feb;10(1):24-31.
The influence of i.v. L-carnitine on parameters of lipid- and nitrogen metabolism was studied during total parenteral nutrition of mini pigs (x: 4077; n = 9). The infusion protocol was divided into isocaloric and isonitrogenous 48-hour-periods. Amino acids (3 g/kg/day) were administered throughout all three periods. 140 Cal/kg/day were given as non-protein calories, consisting only of glucose during period 1. During periods 2 and 3 an amount of glucose calorically equivalent to 4 g fat/kg/day was substituted with a lipid emulsion. In period 3, L-carnitine (1,5 mg/kg/day) was added. During the entire regime key parameters of fat and nitrogen metabolism were determined. During all three periods indirect calorimetry was performed and the respiratory quotient calculated. The results demonstrate a more effective lipolysis and oxydation of fatty acids during L-carnitine supplementation. This results in an increased energy gain from exogenously administered fat and a distinct improvement of nitrogen balance.
在小型猪（体重均值：4077；n = 9）的全胃肠外营养期间，研究了静脉注射L-肉碱对脂质和氮代谢参数的影响。输注方案分为等热量和等氮量的48小时周期。在所有三个周期中均给予氨基酸（3 g/kg/天）。在第1周期，以140 Cal/kg/天的量给予非蛋白质热量，仅由葡萄糖组成。在第2和第3周期，用脂质乳剂替代了热量相当于4 g脂肪/kg/天的葡萄糖量。在第3周期，添加了L-肉碱（1.5 mg/kg/天）。在整个疗程中，测定了脂肪和氮代谢的关键参数。在所有三个周期中均进行了间接测热法并计算了呼吸商。结果表明，补充L-肉碱期间脂肪酸的脂解和氧化更有效。这导致从外源性给予的脂肪中获得的能量增加，并且氮平衡有明显改善。
