Gotthard R, Berstad A, Bodemar G, Norlander B, Walan A
Scand J Gastroenterol. 1983 Sep;18(6):809-17. doi: 10.3109/00365528309182099.
The 24-h intragastric pH, titrated hydrogen ion concentration, and pepsin concentration were studied in nine peptic ulcer patients during administration of placebo and of 800 mg cimetidine given as two or four equal doses. Cimetidine, 400 mg twice daily, was more effective in reducing acidity during morning (p less than 0.05) and overnight (p less than 0.01) than cimetidine, 200 mg four times daily, which, however, was the most effective regimen during the afternoon (p less than 0.05-0.01). During the 24-h period pH values equal to or above 5 were observed for less than 1 h with placebo treatment, for 1.8 h with cimetidine, 200 mg four times daily, and for 4.7 h with cimetidine, 400 mg twice daily. A new histamine H2-receptor antagonist, oxmetidine, was studied in six other patients, also during a 24-h period. Both 400 mg twice daily and 200 mg four times daily of oxmetidine were superior to placebo (p less than 0.05) in reducing intragastric acidity during the entire 24-h period.
在9名消化性溃疡患者服用安慰剂以及分别以两种或四种等量剂量给予800毫克西咪替丁的过程中，研究了其24小时胃内pH值、滴定氢离子浓度和胃蛋白酶浓度。每日两次服用400毫克西咪替丁，在早晨（p<0.05）和夜间（p<0.01）降低胃酸度方面比每日四次服用200毫克西咪替丁更有效，不过，每日四次服用200毫克西咪替丁是下午最有效的给药方案（p<0.05 - 0.01）。在24小时期间，安慰剂治疗时pH值等于或高于5的时间不到1小时，每日四次服用200毫克西咪替丁时为1.8小时，每日两次服用400毫克西咪替丁时为4.7小时。还在另外6名患者中对一种新的组胺H2受体拮抗剂奥美替丁进行了24小时研究。每日两次服用400毫克和每日四次服用200毫克的奥美替丁在降低整个24小时期间胃内酸度方面均优于安慰剂（p<0.05）。
