翁迪妮氏症候群：二甲弗林的治疗试验。

Ondine's curse: therapeutic trial of dimefline.

作者信息

Morimoto T, Nagao H, Matsuda H, Nihno M, Kohri N, Kobayashi H, Kondo T

出版信息

Brain Dev. 1983;5(6):567-71. doi: 10.1016/s0387-7604(83)80061-8.

Abstract

Ondine's curse is a rare disorder characterized by primary failure of central regulation of breathing, resulting in severe hypoventilation during sleep. This report describes a 14-year-old girl with both this disorder and hypergonadotropic hypogonadism. As a therapeutic trial, dimefline was administered orally, which was effective in deepening respiration for certain periods of sleep, during which time blood gas levels improved significantly.

摘要

翁丁氏咒诅综合征是一种罕见的病症，其特征为呼吸中枢调节原发性失灵，导致睡眠期间出现严重通气不足。本报告描述了一名患有此病症以及促性腺激素分泌过多性性腺功能减退的14岁女孩。作为一项治疗试验，口服了回苏灵，该药在某些睡眠时段可有效加深呼吸，在此期间血气水平显著改善。