Delalande J P, Le Page J L, Perramant M, Lozac'h P, Tanguy R L
Ann Fr Anesth Reanim. 1984;3(1):16-21. doi: 10.1016/s0750-7658(84)80093-3.
In order to determine the role of epidural anaesthesia on protein sparing, eighteen patients undergoing major visceral surgery were randomly divided into three different groups according to the mode of anaesthesia used (general anaesthesia, epidural anaesthesia, continuous epidural anaesthesia for 24 h). These patients were intravenously fed for five days postoperatively; their nitrogen balance was studied. Compared with the "general anaesthesia" group, only the daily averages of nitrogen balance of the "continuous epidural" group were significantly better. IN order to correlate stress with nitrogen saving, the early evolution of several parameters (cortisol, glucose, prolactin) used as "stress markers" was studied : there was no evidence of any significant difference between the three groups.
为了确定硬膜外麻醉对节省蛋白质的作用，将18例接受大型内脏手术的患者根据所采用的麻醉方式（全身麻醉、硬膜外麻醉、持续硬膜外麻醉24小时）随机分为三组。这些患者术后接受了5天的静脉营养支持；对他们的氮平衡进行了研究。与“全身麻醉”组相比，只有“持续硬膜外”组的氮平衡日平均值明显更好。为了将应激与氮节省相关联，研究了用作“应激标志物”的几个参数（皮质醇、葡萄糖、催乳素）的早期变化：三组之间没有任何显著差异的证据。
