Sinclair J F, Wiebkin P, Zaitlin L M, Smith E L, Sinclair P R
Biochem Pharmacol. 1984 Jan 15;33(2):187-90. doi: 10.1016/0006-2952(84)90474-x.
Exposure of cultured chick embryo hepatocytes to ethanol, isobutanol, or isopentanol, the predominant alcohols present in commercial alcoholic beverages, resulted in increased metabolism of aminopyrine or biphenyl by the intact cells. The increases correlated with induction of cytochrome P-450. Hydroxylation of biphenyl at the 4-position was preferentially increased in cells pretreated with either the alcohols or propylisopropylacetamide, a barbiturate-like inducer of cytochrome P-450. In contrast, exposure of the cells to 3,4,3',4'-tetrachlorobiphenyl, a planar polycyclic aromatic hydrocarbon inducer of P-450, resulted in preferential increased hydroxylation at the 2- and 3-positions of biphenyl.
将培养的鸡胚肝细胞暴露于商业酒精饮料中主要存在的乙醇、异丁醇或异戊醇中，会导致完整细胞对氨基比林或联苯的代谢增加。这些增加与细胞色素P-450的诱导相关。在用醇类或丙基异丙基乙酰胺（一种细胞色素P-450的巴比妥类诱导剂）预处理的细胞中，联苯在4位的羟基化优先增加。相比之下，将细胞暴露于3,4,3',4'-四氯联苯（一种P-450的平面多环芳烃诱导剂）中，会导致联苯在2位和3位的羟基化优先增加。
