人外周血多形核白细胞生成血栓素
Thromboxane generation by human peripheral blood polymorphonuclear leukocytes.
作者信息
Goldstein I M, Malmsten C L, Kindahl H, Kaplan H B, Rådmark O, Samuelsson B, Weissmann G
出版信息
J Exp Med. 1978 Sep 1;148(3):787-92. doi: 10.1084/jem.148.3.787.
Abstract
Human peripheral blood polymorphonuclear leukocytes were stimulated to generate thromboxane B2 in a time- and concentration-dependent fashion upon exposure to serum-treated zymosan particles. Conversion by stimulated PMN of [14C] arachidonic acid to [14C]thromboxane B2 was confirmed by thin-layer radiochromatography, radio-gas chromatography, and mass spectrometry. Generation of thromboxane B2 was independent of platelet contamination and could be inhibited by the cyclooxygenase inhibitor, indomethacin. Cells rendered incapable of ingesting particles by treatment with cytochalasin B generated comparable amounts of thromboxane B2. These results suggest that human peripheral blood polymorphonuclear leukocytes synthesize thromboxanes in response to surface stimulation independently of phagocytosis.
摘要
当暴露于血清处理的酵母聚糖颗粒时，人外周血多形核白细胞会以时间和浓度依赖性方式被刺激产生血栓素B2。通过薄层放射色谱法、放射气相色谱法和质谱法证实了受刺激的多形核白细胞将[14C]花生四烯酸转化为[14C]血栓素B2。血栓素B2的产生与血小板污染无关，并且可被环氧化酶抑制剂吲哚美辛抑制。用细胞松弛素B处理而无法摄取颗粒的细胞产生了相当数量的血栓素B2。这些结果表明，人外周血多形核白细胞在受到表面刺激时会独立于吞噬作用合成血栓素。
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本文引用的文献
1
Gas chromatography--mass spectrometry of O-methyloxime derivatives of prostaglandins.前列腺素O-甲基肟衍生物的气相色谱-质谱分析
Chem Phys Lipids. 1969 Sep;3(3):254-72. doi: 10.1016/0009-3084(69)90017-6.
2
Remodeling of granulocyte membrane fatty acids during phagocytosis.吞噬作用期间粒细胞膜脂肪酸的重塑
J Clin Invest. 1974 Mar;53(3):726-34. doi: 10.1172/JCI107611.
3
Aggregation and release reaction induced in human blood platelets by zymosan.酵母聚糖诱导人血小板的聚集和释放反应。
J Immunol. 1974 Mar;112(3):1219-30.
4
Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.两种引起血小板聚集的前列腺素内过氧化物的分离与结构
Proc Natl Acad Sci U S A. 1974 Feb;71(2):345-9. doi: 10.1073/pnas.71.2.345.
5
Cytochalasin B: effect on lysosomal enzyme release from human leukocytes.细胞松弛素B：对人白细胞溶酶体酶释放的影响
Proc Natl Acad Sci U S A. 1973 Mar;70(3):844-8. doi: 10.1073/pnas.70.3.844.
6
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.前列腺素内过氧化物。人血小板中花生四烯酸的新转化。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4. doi: 10.1073/pnas.71.9.3400.
7
Prostaglandin endoperoxides IX. Characterization of rabbit aorta contracting substance (RCS) from guinea pig lung and human platelets.前列腺素内过氧化物IX。豚鼠肺和人血小板中兔主动脉收缩物质（RCS）的特性。
Acta Physiol Scand. 1975 Jun;94(2):222-8. doi: 10.1111/j.1748-1716.1975.tb05881.x.
8
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Proc Natl Acad Sci U S A. 1975 Aug;72(8):2994-8. doi: 10.1073/pnas.72.8.2994.
9
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Acta Physiol Scand. 1976 Nov;98(3):285-94. doi: 10.1111/j.1748-1716.1976.tb10313.x.
10
Polymorphonuclear leukocytes produce thromboxane A2-like activity during phagocytosis.
Prostaglandins. 1976 Nov;12(5):749-57. doi: 10.1016/0090-6980(76)90050-2.
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