健康受试者和肾小球肾炎患者尿沉渣的蛋白质组成。
Protein composition of urinary casts from healthy subjects and patients with glomerulonephritis.
作者信息
Fairley J K, Owen J E, Birch D F
出版信息
Br Med J (Clin Res Ed). 1983 Dec 17;287(6408):1838-40. doi: 10.1136/bmj.287.6408.1838.
Abstract
Urinary casts from 46 healthy volunteers and 60 patients with glomerulonephritis were examined for the presence of Tamm-Horsfall glycoprotein and other proteins. All samples gave immunofluorescence evidence of Tamm-Horsfall protein in casts. Casts from 59 of the patients but only three of the controls contained other proteins in addition (p less than 0.001). Immunoglobulins (IgG, IgM, IgA) were detected in casts from 53 of the patients but none of the healthy volunteers. Examination of urinary casts for immunoglobulins, complement, and fibrin provides a non-invasive method for distinguishing patients with active glomerular disease.
摘要
对46名健康志愿者和60名肾小球肾炎患者的尿沉渣进行检查，以确定是否存在Tamm-Horsfall糖蛋白和其他蛋白质。所有样本的尿沉渣均通过免疫荧光检测显示有Tamm-Horsfall蛋白。59例患者的尿沉渣中除Tamm-Horsfall蛋白外还含有其他蛋白质，而对照组只有3例含有其他蛋白质（p<0.001）。53例患者的尿沉渣中检测到免疫球蛋白（IgG、IgM、IgA），而健康志愿者的尿沉渣中未检测到。检测尿沉渣中的免疫球蛋白、补体和纤维蛋白，为区分活动性肾小球疾病患者提供了一种非侵入性方法。
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