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1
Vitamin A treatment for night blindness in primary biliary cirrhosis.维生素A治疗原发性胆汁性肝硬化的夜盲症。
Br Med J (Clin Res Ed). 1984 Apr 7;288(6423):1030-1. doi: 10.1136/bmj.288.6423.1030.
2
Dark adaptation compared with electrooculography in primary biliary cirrhosis.
Doc Ophthalmol. 1989 Apr;71(4):397-402. doi: 10.1007/BF00152766.
3
Night blindness in primary biliary cirrhosis.原发性胆汁性肝硬化中的夜盲症
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4
Vitamin A for night-blindness in prolonged jaundice.维生素A用于治疗长期黄疸引起的夜盲症。
Br Med J. 1971 Jul 10;3(5766):92-3. doi: 10.1136/bmj.3.5766.92.
5
Fundus albipunctatus and vitamin A deficiency.
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6
Vitamin A status in different stages of schistosomal cases and the effectiveness of oral vitamin A therapy.
Z Ernahrungswiss. 1990 Dec;29(4):249-55. doi: 10.1007/BF02023081.
7
[Acute reversible night blindness caused by vitamin A deficiency in pancreatic carcinoma].
Klin Monbl Augenheilkd. 1998 Aug;213(2):108-11. doi: 10.1055/s-2008-1034956.
8
Paradoxical increase in dark-adaptation time after vitamin A intake.
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Fundus white spots and acquired night blindness due to vitamin A deficiency.眼底白斑与维生素A缺乏所致的获得性夜盲症。
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Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state.原发性胆汁性肝硬化、暗适应测定法、眼电图及维生素A状态
Br Med J (Clin Res Ed). 1984 Dec 1;289(6457):1484-5. doi: 10.1136/bmj.289.6457.1484.
5
Keratomalacia on a 'healthy diet'.在“健康饮食”情况下发生的角膜软化症。
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6
Vitamin A deficiency in treated cystic fibrosis: case report.经治疗的囊性纤维化患者维生素A缺乏：病例报告。
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7
Dark adaptation compared with electrooculography in primary biliary cirrhosis.
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8
Reformulation of injectable vitamin A.注射用维生素A的重新配方。
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本文引用的文献

1
Vitamin A and zinc therapy in primary biliary cirrhosis.原发性胆汁性肝硬化的维生素A和锌疗法。
Hepatology. 1981 Jul-Aug;1(4):348-51. doi: 10.1002/hep.1840010412.
2
An automated statis perimeter/adaptometer using light emitting diodes.一种使用发光二极管的自动静态视野计/自适应视野计。
Br J Ophthalmol. 1983 Jul;67(7):431-42. doi: 10.1136/bjo.67.7.431.
3
Regulation of retinol-binding protein metabolism by vitamin A status in the rat.维生素A状态对大鼠视黄醇结合蛋白代谢的调节
J Biol Chem. 1972 Apr 25;247(8):2542-50.
4
The localization of the vitamin A in the mouse liver as revealed by electron microscope radioautography.通过电子显微镜放射自显影术揭示的维生素A在小鼠肝脏中的定位。
J Electron Microsc (Tokyo). 1973;22(4):337-46.
5
Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography.通过高压液相色谱法同时测定血浆或红细胞中的α-生育酚和视黄醇。
Am J Clin Nutr. 1979 Oct;32(10):2143-9. doi: 10.1093/ajcn/32.10.2143.

维生素A治疗原发性胆汁性肝硬化的夜盲症。

Vitamin A treatment for night blindness in primary biliary cirrhosis.

作者信息

Walt R P, Kemp C M, Lyness L, Bird A C, Sherlock S

出版信息

Br Med J (Clin Res Ed). 1984 Apr 7;288(6423):1030-1. doi: 10.1136/bmj.288.6423.1030.

DOI:10.1136/bmj.288.6423.1030
PMID:6423181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1442628/
Abstract

Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.

摘要

三名晚期原发性胆汁性肝硬化患者被发现有明显的夜盲症。尽管其中两名患者定期接受肌肉注射补充维生素A，但三名患者的血清维生素A浓度均较低。所有患者对高剂量口服补充剂均有显著反应，暗适应和视野完全恢复。在预防胆汁性肝硬化维生素A缺乏的眼部并发症方面，口服而非肌肉注射维生素A补充剂似乎更为合适。