Woodruff R C, Mason J M, Valencia R, Zimmering S
Environ Mutagen. 1984;6(2):189-202. doi: 10.1002/em.2860060207.
As part of the validation phase of the Drosophila melanogaster segment of the National Toxicology Program, a comparison has been made of positive and negative controls for sex-linked recessive lethal mutations and reciprocal translocations from three laboratories. This comparison involves approximately 700,000 spontaneous recessive lethal mutation tests, 70,000 spontaneous translocation tests, and screens for genetic damage induced by N-nitrosodimethylamine and beta-propiolactone. Spontaneous frequencies for lethal mutations and translocations were homogeneous in the laboratories regardless of solvent or broods sampled. Inhomogeneity was observed in induced frequencies among laboratories, but the variation was no greater than that found within a laboratory.
作为国家毒理学计划中黑腹果蝇部分验证阶段的一部分，对来自三个实验室的性连锁隐性致死突变和相互易位的阳性和阴性对照进行了比较。这种比较涉及大约700,000次自发隐性致死突变试验、70,000次自发易位试验，以及对N-亚硝基二甲胺和β-丙内酯诱导的遗传损伤的筛查。无论所采样的溶剂或育雏如何，各实验室中致死突变和易位的自发频率都是一致的。在各实验室之间观察到诱导频率的不均匀性，但这种变化不大于在一个实验室内发现的变化。
