Woodruff R C, Mason J M, Valencia R, Zimmering S
Environ Mutagen. 1985;7(5):677-702. doi: 10.1002/em.2860070507.
Fifty-three chemicals were tested for mutagenicity in Drosophila melanogaster by adult feeding and, where results were negative, by adult injection for the induction of sex-linked recessive lethal mutations in meiotic and postmeiotic germ cell stages of Canton-S males. One compound was tested by inhalation. Those compounds that induced lethal mutations were tested further for the induction of reciprocal translocations. Seventeen of the 53 compounds (acetaldehyde, 2-aminoanthracene, bromoform, t-butyl hydroperoxide, chlorambucil, trans-cinnamaldehyde, crotonaldehyde, 1,3-dichloro-5,5-dimethylhydantoin, 3,4-dichloronitrobenzene, dimethoxane, 2,4-dinitrotoluene, 1,2-epoxy-3,3,3-trichloropropane, formaldehyde, furfural, halothane, HC yellow 4, and picric acid) were found to induce lethal mutations and three (2-aminoanthracene, chlorambucil,and crotonaldehyde) also induced reciprocal translocations.
通过成虫喂食法对53种化学物质进行了黑腹果蝇致突变性测试，若结果为阴性，则通过成虫注射法，以诱导Canton-S品系雄性果蝇减数分裂期和减数分裂后生殖细胞阶段的性连锁隐性致死突变。对一种化合物进行了吸入测试。对那些诱导产生致死突变的化合物，进一步测试其诱导相互易位的能力。53种化合物中的17种（乙醛、2-氨基蒽、溴仿、叔丁基过氧化氢、苯丁酸氮芥、反式肉桂醛、巴豆醛、1,3-二氯-5,5-二甲基乙内酰脲、3,4-二氯硝基苯、二甲氧烷、2,4-二硝基甲苯、1,2-环氧-3,3,3-三氯丙烷、甲醛、糠醛、氟烷、HC黄4和苦味酸）被发现可诱导致死突变，其中3种（2-氨基蒽、苯丁酸氮芥和巴豆醛）还可诱导相互易位。
