Yoon J S, Mason J M, Valencia R, Woodruff R C, Zimmering S
Environ Mutagen. 1985;7(3):349-67. doi: 10.1002/em.2860070310.
Results from Drosophila mutagenicity tests of 45 chemical compounds assayed for the National Toxicology Program are presented. Nine compounds were judged positive and four equivocal in the sex-linked recessive lethal test. The nine positive compounds were acetin, allyl glycidyl ether, cyclophosphamide, 1,2-dibromo-3-chloropropane, 2,3-dibromo-1-propanol, dimethylcarbamyl chloride, 1,2-epoxy-butane, lasiocarpine, and N-nitrosopiperidine. The results for chloral hydrate, maleic hydrazide, propantheline bromide, and trifluralin were equivocal. Of the nine compounds positive in recessive lethal induction, only two--allyl glycidyl ether and dimethylcarbamyl chloride--failed to induce translocations. The remaining 32 were judged to be nonmutagenic under the conditions used.
本文展示了针对美国国家毒理学计划检测的45种化合物进行果蝇致突变性试验的结果。在性连锁隐性致死试验中，9种化合物被判定为阳性，4种为可疑。9种阳性化合物分别是醋精、烯丙基缩水甘油醚、环磷酰胺、1,2 - 二溴 - 3 - 氯丙烷、2,3 - 二溴 - 1 - 丙醇、二甲基氨基甲酰氯、1,2 - 环氧丁烷、拉斯柯平碱和N - 亚硝基哌啶。水合氯醛、马来酰肼、溴丙胺太林和氟乐灵的结果为可疑。在隐性致死诱导试验中呈阳性的9种化合物中，只有两种——烯丙基缩水甘油醚和二甲基氨基甲酰氯——未能诱导易位。其余32种在所用条件下被判定为无致突变性。
