Bewley G C, Laurie-Ahlberg C C
Genetics. 1984 Mar;106(3):435-48. doi: 10.1093/genetics/106.3.435.
Both second and third chromosome substitution lines isolated from natural populations of Drosophila melanogaster affect the expression of catalase (EC 1.11.1.6) at both the larval and adult stages of development. In each case, the level of catalase activity is strongly related to the level of catalase-specific cross-reacting material. Turnover studies employing the catalase inhibitor 3-amino-1,2,4-triazole were conducted on a selected number of lines. Although the variation in steady state levels of catalase protein was highly significant among lines, variation in intracellular degradation rate was not. These results suggest that the different steady state levels observed among lines largely reflect different rates of catalase synthesis.
从黑腹果蝇自然种群中分离出的第二代和第三代染色体替代系，在幼虫和成虫发育阶段均会影响过氧化氢酶（EC 1.11.1.6）的表达。在每种情况下，过氧化氢酶活性水平与过氧化氢酶特异性交叉反应物质的水平密切相关。对选定的一些品系进行了使用过氧化氢酶抑制剂3-氨基-1,2,4-三唑的周转研究。尽管品系间过氧化氢酶蛋白稳态水平的差异非常显著，但细胞内降解速率的差异却不显著。这些结果表明，品系间观察到的不同稳态水平在很大程度上反映了过氧化氢酶合成速率的差异。
