黑腹果蝇中乙醇脱氢酶（ADH）表达的遗传变异。
Genetic variation in the expression of ADH in Drosophila melanogaster.
作者信息
Maroni G, Laurie-Ahlberg C C, Adams D A, Wilton A N
出版信息
Genetics. 1982 Jul-Aug;101(3-4):431-46. doi: 10.1093/genetics/101.3-4.431.
Abstract
Several chromosomes derived from natural populations have been identified that affect the expression of alcohol dehydrogenase (ADH). Second chromosomes, which also carry the structural gene Adh, show a great deal of polymorphism of genetic elements that determine how much enzyme protein accumulates. The level of enzyme was measured in third instar larvae, 6-to-8-day-old males and in larval fat bodies and alimentary canals. In general, activities in the different organs and stages are highly correlated with one another. One line was found, however, in which the ADH level in the fat body is more than twice the level one would expect on the basis of the activity in alimentary canal. We have also found evidence of third-chromosome elements that affect the level of ADH.
摘要
已经鉴定出一些来自自然种群的染色体，它们会影响乙醇脱氢酶（ADH）的表达。同样携带结构基因Adh的第二染色体，显示出大量遗传元件的多态性，这些遗传元件决定了酶蛋白积累的量。在三龄幼虫、6至8日龄雄性以及幼虫脂肪体和消化道中测量了酶的水平。一般来说，不同器官和阶段的活性彼此高度相关。然而，发现有一条品系，其脂肪体中的ADH水平比根据消化道中的活性所预期的水平高出两倍多。我们还发现了影响ADH水平的第三染色体元件的证据。
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