Laurie-Ahlberg C C, Wilton A N, Curtsinger J W, Emigh T H
Genetics. 1982 Oct;102(2):191-206. doi: 10.1093/genetics/102.2.191.
The genetic component of variation of enzyme activity levels in Drosophila melanogaster was investigated by using 48 second- and 48 third-chromosome isogenic substitution lines derived from natural populations. The results confirm those of our earlier experiments with the same lines and extend them to a number of additional enzymes. All 23 enzymes show a significant genetic component to the variation in one or both sets of lines and only a small part of this variation is accounted for by variation among the lines in the amount of tissue per fly. The magnitude of line effects is, in most cases, considerably larger than the magnitude of environmental and measurement error effects, and the line effects are approximately continuous in distribution. Variation in the geographic origin and karyotype of the chromosomes generally does not contribute to the line component of variation, but allozymes provide an important source of variation for a few of the enzymes. Many of the enzymes show evidence for variation of activity modifiers that are not linked to the structural locus of the enzyme.
通过使用源自自然种群的48个第二染色体和48个第三染色体同基因替代系，研究了黑腹果蝇酶活性水平变异的遗传成分。结果证实了我们早期使用相同品系进行的实验结果，并将其扩展到了许多其他酶。所有23种酶在一组或两组品系的变异中都显示出显著的遗传成分，并且这种变异中只有一小部分是由每只果蝇的组织量在品系间的变异所导致的。在大多数情况下，品系效应的大小远大于环境和测量误差效应的大小，并且品系效应在分布上大致是连续的。染色体的地理起源和核型的变异通常对品系变异成分没有贡献，但对于少数几种酶来说，等位酶是变异的重要来源。许多酶显示出存在与酶的结构基因座不连锁的活性修饰因子变异的证据。
