Spech H J
Klin Wochenschr. 1978 Apr 15;56(8):399-404. doi: 10.1007/BF01477294.
Arterial and venous plasma concentrations of total immunoreactive angiotensin II (AT II), its bioactive hepta-octapeptide fraction and its inactive hexapeptide were measured in normal subjects (n=16), in patients with acute viral hepatitis (n=12), and in treated (n=16) and untreated (n=17) patients with cirrhosis of the liver and ascites. Independent of normal or increased values of total immunoreactive AT II, the ratio between the hepta-octapeptides and the hexapeptide remained unchanged. This might indicate continuous octapeptide generation and balanced metabolite turnover throughout the systemic circulation. Moreover, a significant arterio-venous peptide gradient was lacking. It has to be concluded that total venous plasma AT II sufficiently reflects both the arterial hormone concentration and its major fraction of hepta-octapeptides in arterial (79%) and venous (76%) blood.
在正常受试者（n = 16）、急性病毒性肝炎患者（n = 12）以及有腹水的肝硬化治疗患者（n = 16）和未治疗患者（n = 17）中，测量了动脉和静脉血浆中总免疫反应性血管紧张素II（AT II）、其生物活性七肽 - 八肽部分及其无活性六肽的浓度。无论总免疫反应性AT II的值正常或升高，七肽 - 八肽与六肽之间的比例保持不变。这可能表明在整个体循环中八肽持续生成且代谢产物周转平衡。此外，不存在明显的动静脉肽梯度。必须得出结论，静脉血浆中总AT II足以反映动脉血（79%）和静脉血（76%）中动脉激素浓度及其七肽 - 八肽的主要部分。
