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[利用药理学试验对机体反应性的研究]

[Study of the body's reactivity using pharmacological tests].

作者信息

Krupina T N, Iarullin Kh Kh, Tizul A Ia, Barkhatova V P, Aleksandrova M P

出版信息

Kosm Biol Aviakosm Med. 1978 Mar-Apr;12(2):19-24.

PMID:642416
Abstract

Variations in the excretion of catecholamines (adrenalin, noradrenalin, dopamine and DOPA precursor) were studied in 34 test subjects who had undergone two drug tests at a two day interval: an insulin test at a dose of 0.15 Units/kg body weight and dopavein test at a dose of 800 microgram/day. In most cases these drugs caused an adequate response of the sympathoadrenal system which included its increased activity and reflected nonspecific reactions. It is concluded that a high (or an adequate) relative activity of the sympathoadrenal system during these tests is more favorable in terms of prediction of reactions of the body in harsh environments than a decreased activity of the sympatho-adrenal system, especially when it is combined with low background values of catecholamine excretion.

摘要

对34名受试对象的儿茶酚胺(肾上腺素、去甲肾上腺素、多巴胺和多巴前体)排泄变化进行了研究,这些受试对象在两天的间隔内接受了两次药物测试:一次是剂量为0.15单位/千克体重的胰岛素测试,另一次是剂量为800微克/天的多巴胺静脉测试。在大多数情况下,这些药物引起了交感肾上腺系统的充分反应,包括其活动增加,并反映了非特异性反应。得出的结论是,在这些测试中,交感肾上腺系统的高(或充分)相对活性在预测身体在恶劣环境中的反应方面比交感肾上腺系统活性降低更有利,尤其是当它与儿茶酚胺排泄的低背景值相结合时。

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