Iakovleva V I
Kosm Biol Aviakosm Med. 1978 Mar-Apr;12(2):61-7.
In order to estimate end effects of chronic prolonged gammairradiation of dogs, an exposure of 80 animals to irradiation was terminated and they were followed up closely. Out of 80 animals 30 dogs (1st series) were irradiated for 3 years and 50 dogs (II series) for 6 years. The dogs were exposed to irradiation at doses of 21 to 190 rad per year. Out of the total number of animals 22 dogs died. Post-mortem examinations showed neoformations in 13 animals (7 malignant and 12 benign neoformations). The highest number of tumors developed in dogs of the II series (10 out of 11) one-two years after irradiation (6 malignant tumors--malignant pheochromocytoma of adrenals; malignant adenoma of the hypophysis: polymorphocellular sarcoma of the liver; leucomyosarcoma of the uterus; bladder cancer; breast cancer; and 10 benign tumors--pancreatic adenoma; liver angioma; 2 papillary adenomas of the prostate; 3 renal adenomas; lipoma; polyps of the gall-bladder). Animals of the 1st series displayed 3 neoformations (1 malignant tumor--bladder tumor and 2 benign tumorsliver hepatoma and spleen angioma) 4--5 years after irradiation.
为了评估犬长期慢性γ射线辐射的终末效应，对80只接受辐射的动物停止照射并进行密切随访。80只动物中，30只犬（第一组）接受了3年照射，50只犬（第二组）接受了6年照射。犬每年接受21至190拉德的辐射剂量。在所有动物中，22只犬死亡。尸检显示13只动物出现新生物（7个恶性和12个良性新生物）。第二组犬在照射后1至2年出现的肿瘤数量最多（11只中有10只）（6个恶性肿瘤——肾上腺恶性嗜铬细胞瘤；垂体恶性腺瘤；肝多形细胞肉瘤；子宫平滑肌肉瘤；膀胱癌；乳腺癌；以及10个良性肿瘤——胰腺腺瘤；肝血管瘤；前列腺2个乳头状腺瘤；3个肾腺瘤；脂肪瘤；胆囊息肉）。第一组动物在照射后4至5年出现3个新生物（1个恶性肿瘤——膀胱肿瘤和2个良性肿瘤——肝肝癌和脾血管瘤）。
