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[23种化疗药物对从粪便中分离出的空肠弯曲菌/结肠弯曲菌菌株的体外活性]

[In vitro activity of 23 chemotherapeutic agents against Campylobacter jejuni/coli strains isolated from feces].

作者信息

Holländer R

出版信息

Zentralbl Bakteriol Mikrobiol Hyg A. 1983 Dec;256(2):196-201.

PMID:6424358
Abstract

In vitro susceptibility of 256 C. jejuni/coli-isolates to 23 antimicrobial agents were tested by an agar-diffusion technique and by determination of the minimal inhibition concentrations. The isolates tested were highly susceptible to tetracycline, the aminoglycosides, chloramphenicol, nitrofurantoin, and pipemic acid. They were resistant to cephalosporins (except Cefotaxime) and penicillin and its derivatives. About 6% of the isolates were resistant to erythromycin (MIC 4 micrograms/ml) and about 15% to nalidixic acid (MIC 40 micrograms/ml). The significance of the resistance patterns of C. jejuni/coli strains for therapy and taxonomic problems was discussed.

摘要

采用琼脂扩散技术并通过测定最小抑菌浓度,对256株空肠弯曲菌/结肠弯曲菌分离株对23种抗菌药物的体外敏感性进行了检测。所检测的分离株对四环素、氨基糖苷类、氯霉素、呋喃妥因和吡哌酸高度敏感。它们对头孢菌素(除头孢噻肟外)、青霉素及其衍生物耐药。约6%的分离株对红霉素耐药(MIC为4微克/毫升),约15%对萘啶酸耐药(MIC为40微克/毫升)。讨论了空肠弯曲菌/结肠弯曲菌菌株耐药模式在治疗和分类学问题中的意义。

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