Karmali M A, De Grandis S, Fleming P C
Antimicrob Agents Chemother. 1981 Apr;19(4):593-7. doi: 10.1128/AAC.19.4.593.
Agar dilution antimicrobial susceptibility testing of Camphylobacter jejuni showed that erythromycin, clindamycin, nitrofurantoin, and gentamicin were the most active compounds, inhibiting 90% of the isolates at a concentration of 1 microgram/ml or less. The frequency of high-level erythromycin resistance was 1%. Erythromycin-resistant isolates showed cross-resistance to clindamycin. All strains were inhibited by chloramphenicol at less than or equal to 8 micrograms/ml. About 20% of the isolates were resistant to tetracycline at 4 micrograms/ml. All strains were highly resistant to novobiocin, bacitracin, vancomycin, and trimethoprim and resistant to rifampin. The minimal inhibitory concentrations (MICs) of metronidazole ranged from less than or equal to 0.5 to 128 micrograms/ml. The susceptibility of strains to sulfamethoxazole and polymyxin B sulfate was markedly influenced by inoculum size. The MICs of polymyxin B sulfate were significantly higher at 42 than 36 degrees C. All strains were inhibited by nalidixic acid at 32 micrograms/ml. In the penicillin group, ampicillin was the most active compound, inhibiting only about three-quarters of the strains at 8 micrograms/ml. The cephalosporins as a group showed only moderate to poor activity, the most active cephalosporin being cefotaxime, which inhibited about 90% of the strains at 8 micrograms/ml. The use of antibiotics in selective media is discussed.
空肠弯曲菌的琼脂稀释法抗菌药敏试验表明，红霉素、克林霉素、呋喃妥因和庆大霉素是最具活性的化合物，在浓度为1微克/毫升或更低时可抑制90%的分离株。高水平红霉素耐药的频率为1%。耐红霉素的分离株对克林霉素表现出交叉耐药。所有菌株在氯霉素浓度小于或等于8微克/毫升时均被抑制。约20%的分离株对4微克/毫升的四环素耐药。所有菌株对新生霉素、杆菌肽、万古霉素和甲氧苄啶高度耐药，对利福平耐药。甲硝唑的最低抑菌浓度（MIC）范围为小于或等于0.5至128微克/毫升。菌株对磺胺甲恶唑和硫酸多粘菌素B的敏感性受接种量的显著影响。硫酸多粘菌素B在42℃时的MIC显著高于36℃时。所有菌株在32微克/毫升的萘啶酸作用下均被抑制。在青霉素组中，氨苄西林是最具活性的化合物，在8微克/毫升时仅能抑制约四分之三的菌株。头孢菌素类作为一个整体仅表现出中度至较差的活性，最具活性的头孢菌素是头孢噻肟，在浓度为8微克/毫升时可抑制约90%的菌株。文中讨论了在选择性培养基中使用抗生素的情况。
