Scheithauer B W, Carpenter P C, Bloch B, Brazeau P
Am J Med. 1984 Apr;76(4):605-16. doi: 10.1016/0002-9343(84)90284-5.
Rarely, acromegaly is produced by neuroendocrine neoplasms elaborating a substance similar to or identical with growth hormone-releasing factor. This report reviews the cases described to date and presents the clinicopathologic features of a patient with acromegaly, mild sellar enlargement, and elevated growth hormone levels associated with a large bronchial carcinoid tumor. Normalization of serum growth hormone levels and regression of acromegaly followed resection of the bronchial tumor, which was shown, by bioassay and immunocytochemistry, to contain a growth hormone-releasing factor.
极少数情况下，肢端肥大症由分泌与生长激素释放因子相似或相同物质的神经内分泌肿瘤引起。本报告回顾了迄今为止所描述的病例，并呈现了一名患有肢端肥大症、轻度蝶鞍增大且生长激素水平升高的患者的临床病理特征，该患者与一个大的支气管类癌肿瘤相关。切除支气管肿瘤后，血清生长激素水平恢复正常，肢端肥大症消退，通过生物测定和免疫细胞化学显示，该肿瘤含有生长激素释放因子。
