Bostwick D G, Quan R, Hoffman A R, Webber R J, Chang J K, Bensch K G
Am J Pathol. 1984 Nov;117(2):167-70.
Seventy-three human tumors and adjacent nonneoplastic tissues were analyzed immunohistochemically for the presence of growth-hormone-releasing factor (GRF). Four of 9 pancreatic endocrine tumors, 2 of 3 appendiceal carcinoids, and 1 of 5 cecal carcinoids were immunoreactive for GRF. One of the GRF-containing pancreatic tumors was associated with acromegaly. Histologically, the growth patterns of these tumors were variable, and the distribution of immunoreactive cells was patchy and irregular. There were no normal cells that contained GRF. These results indicate that GRF production by human tumors is more common than previously thought, although clinical acromegaly may not be apparent in patients who harbor such neoplasms.
采用免疫组织化学方法分析了73例人类肿瘤及其相邻的非肿瘤组织中生长激素释放因子（GRF）的存在情况。9例胰腺内分泌肿瘤中有4例、3例阑尾类癌中有2例、5例盲肠类癌中有1例对GRF呈免疫反应性。其中1例含GRF的胰腺肿瘤与肢端肥大症相关。从组织学上看，这些肿瘤的生长模式各不相同，免疫反应性细胞的分布呈斑片状且不规则。不存在含有GRF的正常细胞。这些结果表明，人类肿瘤产生GRF的情况比以前认为的更为常见，尽管患有此类肿瘤的患者可能没有明显的临床肢端肥大症表现。
