在用多胺抗代谢物治疗艾氏腹水癌荷瘤小鼠过程中，肠道来源的二胺向肿瘤细胞的转移。
Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.
作者信息
Kallio A, Nikula P, Jänne J
出版信息
Biochem J. 1984 Mar 1;218(2):641-4. doi: 10.1042/bj2180641.
Abstract
Treatment of Ehrlich-ascites-carcinoma-bearing mice with methylglyoxal bis(guanylhydrazone) alone or in combination with 2-difluoromethylornithine greatly enhanced the transfer of intragastrically administered radioactive putrescine and cadaverine into the carcinoma cells. Difluoromethylornithine alone did not have any effect on the accumulation of intestine-derived diamines in the tumour cells. The frequently reported restoration of difluoromethylornithine-induced polyamine depletion on administration of methylglyoxal bis(guanylhydrazone) is in all likelihood attributable to a profound inhibition of intestinal diamine oxidase (EC 1.4.3.6), resulting in an enhanced entry of intestinal (bacterial) diamines into general circulation and finally into tumour cells.
摘要
单独使用甲基乙二醛双（胍腙）或与二氟甲基鸟氨酸联合治疗携带艾氏腹水癌的小鼠，极大地增强了胃内给予的放射性腐胺和尸胺向癌细胞的转运。单独使用二氟甲基鸟氨酸对肿瘤细胞中肠源性二胺的积累没有任何影响。经常报道的在给予甲基乙二醛双（胍腙）后二氟甲基鸟氨酸诱导的多胺耗竭的恢复，很可能归因于对肠二胺氧化酶（EC 1.4.3.6）的深度抑制，导致肠（细菌）二胺进入体循环并最终进入肿瘤细胞的量增加。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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2
Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.通过干扰多胺生物合成抑制EMT6肿瘤生长；鸟氨酸脱羧酶不可逆抑制剂α-二氟甲基鸟氨酸的作用
Life Sci. 1980 Jan 21;26(3):181-94. doi: 10.1016/0024-3205(80)90292-1.
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Methylglyoxal bis(guanylhydrazone) stimulates the cellular transport system of the polyamines.甲基乙二醛双（脒腙）刺激多胺的细胞转运系统。
FEBS Lett. 1982 Aug 23;145(2):182-6. doi: 10.1016/0014-5793(82)80163-4.
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Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.两种多胺抗代谢物的协同作用导致儿童白血病迅速产生治疗反应。
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Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats.α-二氟甲基鸟氨酸单独及与阿霉素或长春地辛联合应用对小鼠L1210白血病、小鼠EMT6实体瘤以及大鼠接种肝癌组织培养细胞诱导的实体瘤的影响。
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Death of tumor cells in response to the use of a system of stimulated polyamine uptake from the transport of methylglyoxal bis(guanylhydrazone).肿瘤细胞因使用一种从甲基乙二醛双（胍腙）转运中刺激多胺摄取的系统而死亡。
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