通过干扰多胺生物合成抑制EMT6肿瘤生长；鸟氨酸脱羧酶不可逆抑制剂α-二氟甲基鸟氨酸的作用 - Suppr

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Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.

作者信息

Prakash N J, Schechter P J, Mamont P S, Grove J, Koch-Weser J, Sjoerdsma A

出版信息

Life Sci. 1980 Jan 21;26(3):181-94. doi: 10.1016/0024-3205(80)90292-1.

DOI:10.1016/0024-3205(80)90292-1

PMID:7360002

Abstract

摘要

相似文献

Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.通过干扰多胺生物合成抑制EMT6肿瘤生长；鸟氨酸脱羧酶不可逆抑制剂α-二氟甲基鸟氨酸的作用

Life Sci. 1980 Jan 21;26(3):181-94. doi: 10.1016/0024-3205(80)90292-1.

Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.多胺生物合成与皮肤肿瘤促进作用：鸟氨酸脱羧酶不可逆抑制剂α-二氟甲基鸟氨酸对12-O-十四烷酰佛波醇-13-乙酸酯促进的小鼠皮肤肿瘤形成的抑制作用

Biochem Biophys Res Commun. 1982 Apr 14;105(3):969-76. doi: 10.1016/0006-291x(82)91065-8.

[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].[多胺生物合成抑制剂治疗难治性前列腺癌的实验与临床研究]

Onkologie. 1985 Aug;8(4):196-200. doi: 10.1159/000215710.

Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.多胺合成抑制剂对实验性前列腺癌的一些影响。

Arzneimittelforschung. 1984;34(1):36-9.

Inhibition of polyamine biosynthesis by alpha-difluoromethyl ornithine potentiates the cytotoxic effects of arabinosyl cytosine in HeLa cells.α-二氟甲基鸟氨酸对多胺生物合成的抑制作用增强了阿糖胞苷对HeLa细胞的细胞毒性作用。

Biochem Biophys Res Commun. 1980 Jul 16;95(1):423-30. doi: 10.1016/0006-291x(80)90755-x.

Effects of DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, on the rat mammary tumour induced by 7,12-dimethylbenz[a]anthracene.鸟氨酸脱羧酶不可逆抑制剂DL-α-二氟甲基鸟氨酸对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤的影响。

Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):72-7. doi: 10.1007/BF00499076.

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues.α-二氟甲基鸟氨酸（一种鸟氨酸脱羧酶的酶激活不可逆抑制剂）对大鼠组织中多胺水平的影响。

Life Sci. 1979 Feb 5;24(6):519-24. doi: 10.1016/0024-3205(79)90173-5.

Enhancement of ovulation in the rat by DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.鸟氨酸脱羧酶不可逆抑制剂DL-α-二氟甲基鸟氨酸对大鼠排卵的促进作用。

Eur J Pharmacol. 1982 May 21;80(2-3):263-6. doi: 10.1016/0014-2999(82)90066-8.

Inhibitors of polyamine biosynthesis. 3. (+/-)-5-Amino-2-hydrazine-2-methylpentanoic acid, an inhibitor of ornithine decarboxylase.多胺生物合成抑制剂。3. （±）-5-氨基-2-肼基-2-甲基戊酸，一种鸟氨酸脱羧酶抑制剂。

J Med Chem. 1975 Sep;18(9):945-8. doi: 10.1021/jm00243a017.

Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase.DL-α-二氟甲基鸟氨酸（一种鸟氨酸脱羧酶的催化性不可逆抑制剂）对细胞增殖的抑制作用。

Acta Chem Scand B. 1980;34(6):457-8. doi: 10.3891/acta.chem.scand.34b-0457.

引用本文的文献

Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer.癌症药物预防：针对多胺代谢来管理结肠癌的风险因素。

J Biol Chem. 2018 Nov 30;293(48):18770-18778. doi: 10.1074/jbc.TM118.003343. Epub 2018 Oct 24.

Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity.草贝西丁是一种具有抗肿瘤活性的新型鸟氨酸脱羧酶变构抑制剂。

Cancer Res. 2016 Mar 1;76(5):1146-1157. doi: 10.1158/0008-5472.CAN-15-0442. Epub 2015 Dec 16.

Failure of treatment with alpha-difluoromethylornithine against secondary multilocular echinococcosis in mice.α-二氟甲基鸟氨酸治疗小鼠继发性多房棘球蚴病失败。

Parasitol Res. 1993;79(1):75-6. doi: 10.1007/BF00931222.

alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.α-二氟甲基鸟氨酸是鸟氨酸脱羧酶的不可逆抑制剂，可抑制肿瘤启动子诱导的小鼠皮肤多胺积累和致癌作用。

Proc Natl Acad Sci U S A. 1982 Oct;79(19):6028-32. doi: 10.1073/pnas.79.19.6028.

Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):72-7. doi: 10.1007/BF00499076.

Difluoromethylornithine irreversibly inactivates ornithine decarboxylase of Pseudomonas aeruginosa, but does not inhibit the enzymes of Escherichia coli.二氟甲基鸟氨酸可使铜绿假单胞菌的鸟氨酸脱羧酶不可逆地失活，但不抑制大肠杆菌的酶。

Biochem J. 1981 Oct 15;200(1):69-75. doi: 10.1042/bj2000069.

Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.在大鼠肝癌细胞中，亚精胺对S-腺苷-L-甲硫氨酸脱羧酶进行严格负调控的间接证据。

Biochem J. 1981 May 15;196(2):411-22. doi: 10.1042/bj1960411.

Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.在用多胺抗代谢物治疗艾氏腹水癌荷瘤小鼠过程中，肠道来源的二胺向肿瘤细胞的转移。

Biochem J. 1984 Mar 1;218(2):641-4. doi: 10.1042/bj2180641.

Role of diamine oxidase during the treatment of tumour-bearing mice with combinations of polyamine anti-metabolites.二胺氧化酶在荷瘤小鼠用多胺抗代谢物组合治疗过程中的作用

Biochem J. 1983 Jun 15;212(3):895-8. doi: 10.1042/bj2120895.

Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.多胺生物合成是维持大鼠外周血细胞成分所必需的。

Proc Natl Acad Sci U S A. 1983 Aug;80(16):5090-3. doi: 10.1073/pnas.80.16.5090.

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