Sharma B K, Smits B J, Robinson R, Burns S, Trounson E N
Br Med J (Clin Res Ed). 1984 Apr 14;288(6424):1111-2. doi: 10.1136/bmj.288.6424.1111.
A middle aged woman referred for an abdominal mass was found to have large amounts of dopa (3-4-dihydroxyphenylalanine) metabolites in her urine. At operation a tumour affecting almost the entire left lobe of the liver was removed. Histologically the tumour was a metastatic carcinoid. After operation the excretion of dopa metabolites fell substantially, confirming that the tumour was the source. Apparently, owing to an enzyme defect the tumour had been unable to decarboxylate dopa. These findings are further evidence of a neural origin for the endocrine system of the gut.
一名因腹部肿块前来就诊的中年女性，其尿液中被发现含有大量多巴（3 - 4 - 二羟基苯丙氨酸）代谢物。手术时切除了一个几乎累及整个肝左叶的肿瘤。组织学检查显示该肿瘤为转移性类癌。术后多巴代谢物的排泄量大幅下降，证实该肿瘤就是来源。显然，由于酶缺陷，肿瘤无法将多巴脱羧。这些发现进一步证明了肠道内分泌系统的神经起源。
