Goedert M, Otten U, Suda K, Heitz P U, Stalder G A, Obrecht J P, Holzach P, Allgöwer M
Cancer. 1980 Jan 1;45(1):104-7. doi: 10.1002/1097-0142(19800101)45:1<104::aid-cncr2820450119>3.0.co;2-i.
Substantial amounts of both dopamine and norepinephrine in addition to serotonin were found in a mesenteric metastasis of an ileal carcinoid tumor. Correspondingly, the norepinephrine-synthesizing enzymes were present in the tumor tissue and tyrosine hydroxylase was found in amounts substantially higher than the levels normally present in adrenal medullary cells. These findings confirm that the carcinoid tumors belong to the APUDomas and indicate that catecholamines might play an important role in the pathogenesis of the carcinoid syndrome.
在一例回肠类癌肿瘤的肠系膜转移灶中，除了血清素外，还发现了大量的多巴胺和去甲肾上腺素。相应地，肿瘤组织中存在去甲肾上腺素合成酶，并且发现酪氨酸羟化酶的含量大大高于肾上腺髓质细胞中正常存在的水平。这些发现证实类癌肿瘤属于APUD瘤，并表明儿茶酚胺可能在类癌综合征的发病机制中起重要作用。
