O'Dowd T C, Ribeiro C D, Munro J, West R R, Howells C H, Davis R H
Br Med J (Clin Res Ed). 1984 May 5;288(6427):1349-52. doi: 10.1136/bmj.288.6427.1349.
Thirty nine adult women who were not pregnant and had the urethral syndrome in a general practice underwent detailed microbiological investigations. Patients monitored their own symptoms, and those with persisting symptoms were entered into a randomised controlled trial of treatment with doxycycline and placebo. Chlamydia trachomatis and Neisseria gonorrhoeae were not isolated and fastidious organisms were not causally associated with the urethral syndrome. Treatment with doxycycline showed no benefit; each episode of the urethral syndrome was short and self limiting and there were no recurrences in a median observation period of 12 months.
39名非妊娠成年女性在一家普通诊所患有尿道综合征，她们接受了详细的微生物学检查。患者自行监测症状，症状持续的患者被纳入一项多西环素与安慰剂治疗的随机对照试验。未分离出沙眼衣原体和淋病奈瑟菌，苛求菌与尿道综合征无因果关系。多西环素治疗未显示出益处；尿道综合征的每一次发作都很短暂且具有自限性，在12个月的中位观察期内无复发情况。
