Inui J, Nakamine H, Nishihara T, Takenaka T, Iwahashi Y
Cancer. 1984 Jun 1;53(11):2487-90. doi: 10.1002/1097-0142(19840601)53:11<2487::aid-cncr2820531121>3.0.co;2-e.
A case of malignant lymphoma associated with IgD monoclonal gammopathy is described. Orbital and testicular tumors were observed, while peripheral lymphadenopathy was absent. Neoplastic lymphoid cells appeared in peripheral blood, bone marrow, and pleural effusion with progression of the disease. Analysis of the serum suggested "unreactive" light chain determinants in monoclonal protein. In immunohistochemical studies and in vitro experiments, it was confirmed that IgD monoclonal gammopathy was directly related to the neoplastic cells. These unusual findings suggest that neoplastic changes such as neoplasms of other B-cell systems may occur at various stages in the differentiation and maturation of IgD-forming B-cell lineage.
本文描述了一例与IgD单克隆丙种球蛋白病相关的恶性淋巴瘤。观察到眼眶和睾丸肿瘤，但无外周淋巴结病。随着疾病进展，外周血、骨髓和胸腔积液中出现肿瘤性淋巴细胞。血清分析提示单克隆蛋白中有“无反应性”轻链决定簇。在免疫组织化学研究和体外实验中，证实IgD单克隆丙种球蛋白病与肿瘤细胞直接相关。这些不寻常的发现表明，其他B细胞系统的肿瘤等肿瘤性变化可能发生在形成IgD的B细胞系分化和成熟的不同阶段。
