Alcalay M, Reboux J F, Becq-Giraudon B, Bontoux D
Pathol Biol (Paris). 1975 Apr;23(4):315-21.
Immunoglobulin D is the fourth class of immunoglobulins secreted by the plasma cells and also, in 5% of lymphocytes, this is a surface immunoglobulin. Its serum levels are about 0.03 mg/ml, due to low secretion, intersititial diffusion and intense catabolism. IgD migrates on electrophoresis in the beta-gamma zone, on immuno-electrophoresis, in the beta2 zone. Only one disulphide bridge links the delta-chains together. The light chains, are, in most cases, lambda chain. Studies of the antigenic characteristics of the delta-chains are in progress. IgD does not take up complement, but has an antibody function. 37% of healthy subjects have anti IgD antibodies. Only 4 cases of monoclonal IgD gammopathy without malignant myeloma, have been reported. Anto-antibodies of IgD nature have been described in various connective tissue diseases or auto-immune processes.
免疫球蛋白D是浆细胞分泌的第四类免疫球蛋白，并且在5%的淋巴细胞中，它是一种表面免疫球蛋白。由于其分泌量低、间隙扩散和强烈的分解代谢，其血清水平约为0.03mg/ml。在电泳中，IgD在β-γ区迁移，在免疫电泳中，在β2区迁移。只有一个二硫键将δ链连接在一起。在大多数情况下，轻链是λ链。对δ链抗原特性的研究正在进行中。IgD不结合补体，但具有抗体功能。37%的健康受试者有抗IgD抗体。仅报告了4例无恶性骨髓瘤的单克隆IgD丙种球蛋白病病例。在各种结缔组织疾病或自身免疫过程中已描述了具有IgD性质的自身抗体。
