Birdi A, Gupta S, Gambhir S S
J Surg Oncol. 1984 Apr;25(4):296-9. doi: 10.1002/jso.2930250416.
Plasma histaminase activity has been estimated in 79 patients with squamous cell carcinoma of the cervix. The mean plasma histaminase value is significantly higher in patients than in controls (P less than 0.001). The plasma histaminase activity falls significantly following radiotherapy (P less than 0.001). Pretreatment plasma histaminase values do not show any correlation with clinical stages and the posttreatment values decline significantly but remain higher in clinical stages III and IV than in stages I and II. The increased plasma histaminase activity also reflects the degree of differentiation within the tumor. Further it is noted that the plasma histaminase value is inversely proportional to the radiation response. It is suggested that estimation of plasma histaminase activity can serve as an important marker in assessing the treatment response and monitoring the course of treatment.
对79例子宫颈鳞状细胞癌患者的血浆组胺酶活性进行了评估。患者的血浆组胺酶平均水平显著高于对照组（P<0.001）。放疗后血浆组胺酶活性显著下降（P<0.001）。治疗前血浆组胺酶水平与临床分期无相关性，治疗后水平虽显著下降，但Ⅲ期和Ⅳ期患者仍高于Ⅰ期和Ⅱ期患者。血浆组胺酶活性升高也反映了肿瘤内的分化程度。此外，还发现血浆组胺酶水平与放射反应呈负相关。提示血浆组胺酶活性的评估可作为评估治疗反应和监测治疗过程的重要指标。
