Ettinger D S, Baylin S B, Minaberry D, Abeloff M D, Mellits E D
J Natl Cancer Inst. 1978 Jun;60(6):1239-42. doi: 10.1093/jnci/60.6.1239.
Plasma histaminase (PH) activity only partially reflected the consistently high activity of histaminase in tumor tissue of patients with small cell carcinoma of the lung (SCC). To determine whether heparin might release histaminase from tumor tissue into the circulation as it does from some normal tissues, we studied the response of PH activity to small doses of heparin in 41 patients with SCC and in 57 normal subjects. In patients with SCC, the initial mean PH activity (2.0 U/m) was not different from that in normal subjects (1.7 U/ml). After heparin administration, the mean PH activity was no different between the 2 groups (patients with SCC, 3.1 U/ml; normal subjects, 3.5 U/ml). In both groups, the higher the initial PH activity, the greater the magnitude of the PH activity response to heparin. This relationship was linear (normal subjects, r = 0.88; patients with SCC, r = 0.91). However, in patients with SCC, the increase in post-heparin PH activity, as related to the basal levels, was significantly less than that in normal subjects (P less than 0.001 by analysis of covariance). The data suggested that heparin did not affect the release of histaminase from tumor tissue into plasma to the same degree as it promoted the enzyme's entry from normal tissue sources. The differences between the groups may enable us to differentiate between selected patients with SCC and normal subjects with borderline high PH activity values.
血浆组胺酶（PH）活性仅部分反映了肺小细胞癌（SCC）患者肿瘤组织中组胺酶始终较高的活性。为了确定肝素是否会像从一些正常组织中那样将组胺酶从肿瘤组织释放到循环中，我们研究了41例SCC患者和57名正常受试者中PH活性对小剂量肝素的反应。在SCC患者中，初始平均PH活性（2.0 U/ml）与正常受试者（1.7 U/ml）无差异。给予肝素后，两组之间的平均PH活性无差异（SCC患者为3.1 U/ml；正常受试者为3.5 U/ml）。在两组中，初始PH活性越高，对肝素的PH活性反应幅度越大。这种关系是线性的（正常受试者，r = 0.88；SCC患者，r = 0.91）。然而，在SCC患者中，肝素后PH活性相对于基础水平的增加明显低于正常受试者（协方差分析，P < 0.001）。数据表明，肝素促进组胺酶从正常组织来源进入血浆的程度与它促进组胺酶从肿瘤组织释放到血浆中的程度不同。两组之间的差异可能使我们能够区分选定的SCC患者和PH活性值处于临界高值的正常受试者。
