Kraemer G W, Ebert M H, Lake C R, McKinney W T
Psychopharmacology (Berl). 1984;82(3):266-71. doi: 10.1007/BF00427788.
Social deprivation of rhesus monkeys in infancy results in increased sensitivity to psychotic-like behavioral effects of low doses of d-amphetamine given 2-3 years later. These behavioral effects are associated with increased levels of CSF norepinephrine. These data suggest that social developmental factors could be partially responsible for variation in neurochemical responses and long-lasting differential sensitivity of primates to the psychosis-inducing effects of d-amphetamine.
幼年恒河猴的社会剥夺会导致其对2 - 3年后给予的低剂量右旋苯丙胺的类精神病行为效应更加敏感。这些行为效应与脑脊液中去甲肾上腺素水平升高有关。这些数据表明，社会发育因素可能部分导致了神经化学反应的差异以及灵长类动物对右旋苯丙胺致精神病效应的长期不同敏感性。
