恒河猴中去甲肾上腺素能系统对丙咪嗪长期治疗的适应性变化
Central noradrenergic adaptation to long-term treatment with imipramine in rhesus monkeys.
作者信息
Lerner P, Major L F, Ziegler M, Dendel P S, Ebert M H
出版信息
Brain Res. 1980 Oct 27;200(1):220-4. doi: 10.1016/0006-8993(80)91113-0.
PMID:7417809
Abstract
Rhesus monkeys were treated with the antidepressant drug imipramine; cerebrospinal fluid norepinephrine and dopamine-beta-hydroxylase were measured to assess central noradrenergic activity. Large changes occurred after short-term, but not long-term, treatment. Biochemical stabilization occurs at the time when therapeutic effects are seen in patients.
摘要
恒河猴接受了抗抑郁药物丙咪嗪治疗；测量脑脊液中的去甲肾上腺素和多巴胺-β-羟化酶以评估中枢去甲肾上腺素能活性。短期治疗后出现了较大变化，但长期治疗后未出现。生化稳定出现在患者出现治疗效果之时。
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