一种用于研究药物在人类中的辨别刺激特性的实验范式。

An experimental paradigm for studying the discriminative stimulus properties of drugs in humans.

作者信息

Chait L D, Uhlenhuth E H, Johanson C E

出版信息

Psychopharmacology (Berl). 1984;82(3):272-4. doi: 10.1007/BF00427789.

Abstract

An experimental paradigm for studying the discriminative stimulus effects of drugs in human subjects is presented. The paradigm was tested by training subjects to discriminate 10 mg d-amphetamine from placebo. Subjects who successfully learned the discrimination were then tested with two lower doses of d-amphetamine and with 10 mg diazepam. The discriminative stimulus properties of d-amphetamine were dose-dependent, and in two of five subjects the d-amphetamine stimulus generalized to diazepam. The simplicity and versatility of the paradigm give it the potential for use in a wide variety of experimental and clinical situations.

摘要

本文介绍了一种用于研究药物对人类受试者辨别性刺激作用的实验范式。通过训练受试者区分10毫克右旋苯丙胺和安慰剂来测试该范式。然后，对成功学会辨别的受试者用两种较低剂量的右旋苯丙胺和10毫克地西泮进行测试。右旋苯丙胺的辨别性刺激特性具有剂量依赖性，在五名受试者中有两名受试者中，右旋苯丙胺的刺激作用扩展到了地西泮。该范式的简单性和通用性使其有潜力用于各种实验和临床情况。