James D K, Chiswick M L, Harkes A, Williams M, Hallworth J
Br Med J (Clin Res Ed). 1984 Jun 2;288(6431):1635-8. doi: 10.1136/bmj.288.6431.1635.
The phospholipid content of lung fluid taken from 77 babies during the first day of life was studied. Babies with hyaline membrane disease had low concentrations of the surfactant phospholipids phosphatidylcholine, phosphatidylinositol, and phosphatidylglycerol. The palmitic acid content in phosphatidylcholine was also lower than normal. Surfactant deficiency was not, however, specific for hyaline membrane disease, as similar phospholipid abnormalities were observed in babies with congenital pneumonia and transient tachypnoea of the newborn. These findings have important clinical implications. They are relevant to research into surfactant substitution and cast doubts on the value of the antenatal phospholipid lung profile of amniotic fluid in predicting the risk of hyaline membrane disease.
对77名婴儿出生第一天采集的肺液中的磷脂含量进行了研究。患有透明膜病的婴儿其表面活性物质磷脂（磷脂酰胆碱、磷脂酰肌醇和磷脂酰甘油）浓度较低。磷脂酰胆碱中的棕榈酸含量也低于正常水平。然而，表面活性物质缺乏并非透明膜病所特有，因为在患有先天性肺炎和新生儿短暂性呼吸急促的婴儿中也观察到了类似的磷脂异常。这些发现具有重要的临床意义。它们与表面活性物质替代研究相关，并对羊水产前磷脂肺图谱在预测透明膜病风险方面的价值提出了质疑。
