螺内酯治疗期间睾酮、17-KS、17-β-E2、促卵泡激素-促黄体生成素的变化及多毛症的改善情况

Testosterone, 17 Ks, 17 beta E2 FSH-LH variations and hirsutism modifications during spironolactone therapy.

作者信息

Spandri P, Gangemi M, Nardelli G B, Meneghetti G, Grandesso R, De Salvia D, Ambrosio G B, Predebon O

出版信息

Clin Exp Obstet Gynecol. 1984;11(1-2):49-54.

Abstract

The research here reported concerns 9 hirsute women, four of them with PCO and five with idiopathic hirsutism, who underwent treatment with spironolactone. 4 non hirsute hypertensive cases served as control. For one year hair growth, testosterone, 17 Ks, estradiol and gonadotropins behaviours were studied in all of the patients. Results clearly show that the peripherical response (the hair) to the therapy is only just sufficient, and corresponds to a good reduction of the androgenic hormones in blood. However, there is also an LH gonadotropin secretion reduction which is statistically scarcely significant. If the therapeutic response of hair were good, fetal risk could be prevented with safe and contemporaneous contraception. However, since the response is scarcely sufficient, we do not think this therapy is more advisable than other ones.

摘要

此处报告的研究涉及9名多毛女性，其中4名患有多囊卵巢综合征（PCO），5名患有特发性多毛症，她们接受了螺内酯治疗。4名非多毛的高血压患者作为对照。对所有患者的毛发生长、睾酮、17酮、雌二醇和促性腺激素行为进行了为期一年的研究。结果清楚地表明，治疗对外周（毛发）的反应仅勉强足够，且与血液中雄激素的显著降低相对应。然而，促黄体生成素（LH）促性腺激素的分泌也有减少，在统计学上几乎不显著。如果对毛发的治疗反应良好，可以通过安全且同时进行的避孕措施来预防胎儿风险。然而，由于反应勉强足够，我们认为这种治疗并不比其他治疗更可取。