Anderson K C, Bates M P, Slaughenhoupt B, Schlossman S F, Nadler L M
J Immunol. 1984 Jun;132(6):3172-9.
A monoclonal antibody that defines a new and distinct plasma cell antigen, termed PC-1, was developed against human plasmacytoma cells. This antigen is strongly expressed on normal plasma cells isolated from bone marrow and on abnormal plasma cells isolated from myelomas, plasma cell leukemias, and plasmacytomas. The antigen is not detected on normal T or B lymphocytes, granulocytes, or monocytes, and with the exception of plasma cells, is absent on malignancies of B, T, or myeloid origin. Utilizing pokeweed mitogen to induce human B lymphocyte differentiation in vitro, PC-1 is expressed when B cell determinants are lost and the plasmacytoid morphology, intracytoplasmic immunoglobulin-staining, and surface PCA-1- and T10-staining characteristic of plasma cells appear. This antigen is useful for the study of the terminal stages of normal B cell differentiation to plasma cells, and may offer insight into the heterogeneity of the plasma cell dyscrasias.
一种针对人浆细胞瘤细胞研制出的单克隆抗体，可识别一种新的、独特的浆细胞抗原，称为PC-1。这种抗原在从骨髓分离出的正常浆细胞以及从骨髓瘤、浆细胞白血病和浆细胞瘤中分离出的异常浆细胞上强烈表达。在正常T或B淋巴细胞、粒细胞或单核细胞上未检测到该抗原，并且除浆细胞外，B、T或髓系来源的恶性肿瘤中也不存在该抗原。利用商陆有丝分裂原在体外诱导人B淋巴细胞分化，当B细胞决定簇消失且出现浆细胞样形态、胞质内免疫球蛋白染色以及浆细胞特有的表面PCA-1和T10染色时，PC-1表达。该抗原有助于研究正常B细胞向浆细胞分化的终末阶段，并可能为浆细胞发育异常的异质性提供见解。
