钙在γ干扰素诱导中的作用：钙通道阻滞剂的抑制作用
Role of calcium in gamma interferon induction: inhibition by calcium entry blockers.
作者信息
Dianzani F, Capobianchi M R, Facchini J
出版信息
J Virol. 1984 Jun;50(3):964-5. doi: 10.1128/JVI.50.3.964-965.1984.
Abstract
Mitogen-induced gamma interferon production by human lymphoid cell cultures was studied in the presence of calcium entry blockers. A dose-dependent inhibition was found in the presence of drug concentrations down to 10(-5) M. This finding shows that calcium flow through lymphocyte membranes after oxidation of membrane-bound galactose residues is also critical for triggering interferon production.
摘要
在存在钙通道阻滞剂的情况下，对丝裂原诱导的人淋巴细胞培养物中γ干扰素的产生进行了研究。在药物浓度低至10(-5)M时发现了剂量依赖性抑制。这一发现表明，膜结合半乳糖残基氧化后通过淋巴细胞膜的钙流对于触发干扰素产生也至关重要。
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本文引用的文献
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2
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3
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Proc Natl Acad Sci U S A. 1982 Apr;79(8):2509-13. doi: 10.1073/pnas.79.8.2509.
4
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5
Calcium entry blockers: key issues.钙通道阻滞剂：关键问题。
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6
Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem.钙拮抗剂的比较药理学：硝苯地平、维拉帕米和地尔硫䓬。
Am J Cardiol. 1980 Dec 1;46(6):1047-58. doi: 10.1016/0002-9149(80)90366-5.
7
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