人免疫干扰素：钙离子载体在淋巴细胞中的诱导作用。
Human immune interferon: induction in lymphoid cells by a calcium ionophore.
作者信息
Dianzani F, Monahan T M, Georgiades J, Alperin J B
出版信息
Infect Immun. 1980 Aug;29(2):561-3. doi: 10.1128/iai.29.2.561-563.1980.
Abstract
Human lymphocyte cultures produced interferon after treatment with the calcium ionophore A23187, but not after treatment with potassium ionophore nonactin. Interferon production was detectable between 3 and 6 h after ionophore treatment and reached the maximum level between 12 and 24 h. Ionophore-induced interferon appeared to be immune interferon on the basis of acid lability, lack of neutralization by antibody to leukocyte interferon, slow kinetics of activation of the antiviral state, and molecular characterization by isoelectrofocusing.
摘要
人淋巴细胞培养物在用钙离子载体A23187处理后产生干扰素，但在用钾离子载体无活菌素处理后不产生。在离子载体处理后3至6小时可检测到干扰素产生，并在12至24小时达到最高水平。基于酸不稳定性、白细胞干扰素抗体不能中和、抗病毒状态激活的缓慢动力学以及等电聚焦的分子特征，离子载体诱导的干扰素似乎是免疫干扰素。
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Human immune interferon: induction in lymphoid cells by a calcium ionophore.人免疫干扰素：钙离子载体在淋巴细胞中的诱导作用。
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本文引用的文献
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Mitogenic properties of a calcium ionophore, A23187.钙离子载体A23187的促有丝分裂特性。
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Activation of sea-urchin eggs by a calcium ionophore.用钙离子载体激活海胆卵。
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A23187: a divalent cation ionophore.A23187：一种二价阳离子离子载体。
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The mechanism of calcium ionophore-induced secretion from the rat neurohypophysis.钙离子载体诱导大鼠神经垂体分泌的机制。
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A calcium ionophore stimulating the secretion of catecholamines from the cat adrenal.一种刺激猫肾上腺分泌儿茶酚胺的钙离子载体。
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Proliferation of human peripheral blood lymphocytes induced by A23187, a streptomyces antibiotic.链霉菌抗生素A23187诱导人外周血淋巴细胞增殖
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