Takeuchi H, Takayama H, Konishi T, Tomoyoshi T
J Urol. 1984 Jul;132(1):67-9. doi: 10.1016/s0022-5347(17)49466-3.
The viability and location of bacteria within infection stones were investigated. Many stones were infected with urea-splitting bacteria, such as Proteus mirabilis and Pseudomonas aeruginosa. Large numbers of bacterial impressions and bodies were found in the interstices surrounded by crystals of apatite and struvite from the nuclei to the peripheral layers. The presence of bacterial colonies even in the nuclear portion of the stones suggests that bacteria participate in the initial stone formation as well as in growth of infection stones. Streptococcus faecalis, a nonurea -splitting bacteria, also was found in some infection stones and probably represents a superimposed infection as a result of changes in bacterial flora owing to treatment with antibiotics.
对感染性结石内细菌的生存能力和位置进行了研究。许多结石感染了尿素分解菌，如奇异变形杆菌和铜绿假单胞菌。在从结石核心到外周层的由磷灰石和鸟粪石晶体包围的间隙中发现了大量细菌印记和菌体。即使在结石的核心部分也存在细菌菌落，这表明细菌既参与了结石的初始形成，也参与了感染性结石的生长。粪肠球菌是一种非尿素分解菌，在一些感染性结石中也有发现，它可能是由于使用抗生素导致细菌菌群变化而引起的叠加感染。
