Thakur M L, Seifert C L, Madsen M T, McKenney S M, Desai A G, Park C H
Semin Nucl Med. 1984 Apr;14(2):107-17. doi: 10.1016/s0001-2998(84)80024-0.
The use of neutrophils labeled with gamma-emitting radionuclides has been shown to be acceptable for in vivo kinetic studies as well as for imaging inflammatory foci. Among the gamma-emitting radionuclides, indium-111 appears to be the agent of choice. Labeling neutrophils with 111In, however, is a relatively new technique. Although simple to perform, it involves several stages, none of which could be carried out without problems. These are discussed and the current research aimed at eliminating the problems is outlined. The knowledge of specific chemotactic receptors and surface antigens has stimulated investigations into selective neutrophil labeling that will continue to be challenging and exciting.
已证明，使用标记有发射γ射线放射性核素的中性粒细胞可用于体内动力学研究以及炎症病灶成像。在发射γ射线的放射性核素中，铟-111似乎是首选试剂。然而，用铟-111标记中性粒细胞是一项相对较新的技术。尽管操作简单，但它涉及几个阶段，每个阶段都可能会出现问题。本文将讨论这些问题，并概述目前旨在消除这些问题的研究。对特定趋化受体和表面抗原的了解激发了对选择性中性粒细胞标记的研究，这将继续具有挑战性和令人兴奋。
