Schrire L, Robinson R G, Koornhof H J
S Afr Med J. 1984 Jun 9;65(23):922-4.
An in vitro comparison of the activities of gentamicin, tobramycin, amikacin and netilmicin against selected clinical isolates showed differences in the susceptibility of individual strains to the four drugs, as well as substantial differences in sensitivity patterns between genera. Sensitive strains of Klebsiella and Enterobacter were most susceptible to netilmicin, but amikacin was more active against resistant strains. Tobramycin was most active against sensitive strains of Pseudomonas aeruginosa, but resistant strains were more susceptible to amikacin. In serious infections caused by these Gram-negative bacilli knowledge of the organism's identity and susceptibility may help in the selection of the most suitable aminoglycoside.
对庆大霉素、妥布霉素、阿米卡星和奈替米星针对选定临床分离株的活性进行的体外比较显示，各菌株对这四种药物的敏感性存在差异，而且不同菌属之间的敏感模式也有显著差异。克雷伯菌属和肠杆菌属的敏感菌株对奈替米星最为敏感，但阿米卡星对耐药菌株的活性更强。妥布霉素对铜绿假单胞菌的敏感菌株活性最强，但耐药菌株对阿米卡星更敏感。在由这些革兰氏阴性杆菌引起的严重感染中，了解病原体的种类和敏感性可能有助于选择最合适的氨基糖苷类药物。
