Stanwell-Smith R, Thompson S G, Woolf L
Thromb Res. 1984 May 1;34(3):199-211. doi: 10.1016/0049-3848(84)90003-3.
Blood samples taken at 28 and 34 weeks of pregnancy from 495 women were assayed for factor VIII clotting activity (VIIIC) and factor VIII related antigen (VIIIR) to examine the distribution of these factors and to determine whether there was any relationship with birthweight. There was a small positive relationship of little clinical value between factor VIIIR and birthweight only when birthweight was adjusted for gestational age, sex of infant and parity. In pregnancies resulting in a male infant the level of factor VIIIC was lower at 34 weeks gestation than in pregnancies resulting in a female infant. A greater rise in the ratio of VIIIR/VIIIC was observed in women who had any type of hypertension when compared with normotensive pregnancies, but this was not associated with lower birthweight. Both factors VIIIR and VIIIC at 28 weeks gestation were lower for multiparous than for primiparous women, and were lower for those with eventual greater gestation at birth. Asian women had higher mean factor VIIIC than Caucasian women, a finding independent of the fact that women with blood group O had lower mean levels of factors VIIIR and VIIIC than women of other blood groups.
对495名女性在妊娠28周和34周时采集的血样进行了凝血因子VIII凝血活性（VIIIC）和凝血因子VIII相关抗原（VIIIR）检测，以研究这些因子的分布情况，并确定其与出生体重是否存在关联。仅在对出生体重进行胎龄、婴儿性别及产次校正后，VIIIR与出生体重之间才存在微弱的、临床价值不大的正相关关系。在妊娠晚期出生男婴的孕妇中，妊娠34周时的VIIIC水平低于出生女婴的孕妇。与血压正常的孕妇相比，患有任何类型高血压的孕妇VIIIR/VIIIC比值升高幅度更大，但这与出生体重较低无关。妊娠28周时，经产妇的VIIIR和VIIIC水平均低于初产妇，且最终出生时孕周较大者的这两个因子水平也较低。亚洲女性的平均VIIIC水平高于白种女性，这一发现与O型血女性的VIIIR和VIIIC平均水平低于其他血型女性这一事实无关。
