• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

针对HLA - DR基因产物的抗体表现出CYNAP现象。

Antibodies directed against HLA-DR gene products exhibit the CYNAP phenomenon.

作者信息

Gebel H M, Oldfather J W, Karr R W, Fuller T C, Rodey G E

出版信息

Tissue Antigens. 1984 Mar;23(3):135-40. doi: 10.1111/j.1399-0039.1984.tb00023.x.

DOI:10.1111/j.1399-0039.1984.tb00023.x
PMID:6427971
Abstract

Two well characterized Eighth International Workshop sera, 8w1090 and 8w112 , described to have anti-DR3 and anti-DR5 activity, respectively, were tested by standard and antiglobulin augmented (AHG) complement dependent cytotoxicity (CDC) assays with 21 target cells. We demonstrate that both sera, in fact, have only one antibody (most likely anti-MT2), but have different CYNAP patterns. These observations are discussed with regard to a more complete analysis of antisera that detect gene products of the HLA-DR region.

摘要

通过标准和抗球蛋白增强(AHG)补体依赖细胞毒性(CDC)试验,使用21种靶细胞对两种特征明确的第八届国际研讨会血清8w1090和8w112进行了检测,据说这两种血清分别具有抗DR3和抗DR5活性。我们证明,实际上这两种血清都只有一种抗体(很可能是抗MT2),但具有不同的细胞毒性网络关联模式(CYNAP模式)。针对检测HLA - DR区域基因产物的抗血清进行更全面分析,对这些观察结果进行了讨论。

相似文献

1
Antibodies directed against HLA-DR gene products exhibit the CYNAP phenomenon.针对HLA - DR基因产物的抗体表现出CYNAP现象。
Tissue Antigens. 1984 Mar;23(3):135-40. doi: 10.1111/j.1399-0039.1984.tb00023.x.
2
HLA alloantibodies and the mechanism of the antiglobulin-augmented lymphocytotoxicity procedure.人类白细胞抗原同种抗体与抗球蛋白增强淋巴细胞毒性试验的机制
Hum Immunol. 1997 Aug-Sep;56(1-2):94-105. doi: 10.1016/s0198-8859(97)00174-2.
3
Screening and use of high titered anti-HLA-DR sera in PHA-blast complement fixation and B-lymphocytotoxicity techniques.在PHA刺激淋巴细胞补体结合试验和B淋巴细胞毒性技术中高滴度抗HLA - DR血清的筛选与应用
Tissue Antigens. 1981 Jan;17(1):37-42. doi: 10.1111/j.1399-0039.1981.tb00664.x.
4
Antisera recognising HLA-A, -B and DRW antigens raised in rhesus monkeys.在恒河猴体内产生的识别HLA - A、- B和DRW抗原的抗血清。
Tissue Antigens. 1980 May;15(5):407-18. doi: 10.1111/j.1399-0039.1980.tb00203.x.
5
Assignment of determinants recognized by human alloantisera to HLA-D-subregion molecules by a lysostrip technique.采用溶菌酶洗脱技术将人类同种抗血清识别的决定簇指定给HLA - D亚区分子。
Tissue Antigens. 1986 Apr;27(4):185-95. doi: 10.1111/j.1399-0039.1986.tb01519.x.
6
The molecules recognized by anti-MT2 alloantisera and anti-MT2-like (DRw52) monoclonal antibodies are different.抗MT2同种抗血清和抗MT2样(DRw52)单克隆抗体所识别的分子是不同的。
Hum Immunol. 1985 Apr;12(4):223-33. doi: 10.1016/0198-8859(85)90338-6.
7
Monoclonal mouse anti-I-Ak and anti-I-Ek antibodies cross-reacting with HLA-DR supertypic and subtypic determinants rather than classical DR allelic specificities.与HLA - DR超型和亚型决定簇而非经典DR等位基因特异性发生交叉反应的单克隆小鼠抗I - Ak和抗I - Ek抗体。
Tissue Antigens. 1982 Apr;19(4):289-300. doi: 10.1111/j.1399-0039.1982.tb01452.x.
8
[Anti-HLA-DR antibodies in the sera of multigravidae in labor].
Riv Emoter Immunoematol. 1980;27(3-4):151-5.
9
Allo-immune anti-Iak sera of individual mice detect HLA-DR-associated polymorphism on human B cells.个体小鼠的同种免疫抗Iak血清可检测人类B细胞上与HLA - DR相关的多态性。
Tissue Antigens. 1983 Aug;22(2):134-41. doi: 10.1111/j.1399-0039.1983.tb01179.x.
10
Anti-idiotypic antibodies to HLA-DR4 and DR2.针对HLA - DR4和DR2的抗独特型抗体。
J Immunol. 1983 Dec;131(6):2890-4.

引用本文的文献

1
Application and interpretation of histocompatibility data in pediatric kidney transplantation.组织相容性数据在小儿肾移植中的应用与解读
Curr Opin Organ Transplant. 2017 Aug;22(4):426-432. doi: 10.1097/MOT.0000000000000425.
2
Transplant immuno-diagnostics: crossmatch and antigen detection.移植免疫诊断:交叉配型与抗原检测。
Pediatr Nephrol. 2016 Jun;31(6):897-905. doi: 10.1007/s00467-015-3145-z. Epub 2015 Jul 3.