针对HLA - DR基因产物的抗体表现出CYNAP现象。

Antibodies directed against HLA-DR gene products exhibit the CYNAP phenomenon.

作者信息

Gebel H M, Oldfather J W, Karr R W, Fuller T C, Rodey G E

出版信息

Tissue Antigens. 1984 Mar;23(3):135-40. doi: 10.1111/j.1399-0039.1984.tb00023.x.

DOI:10.1111/j.1399-0039.1984.tb00023.x

Abstract

Two well characterized Eighth International Workshop sera, 8w1090 and 8w112 , described to have anti-DR3 and anti-DR5 activity, respectively, were tested by standard and antiglobulin augmented (AHG) complement dependent cytotoxicity (CDC) assays with 21 target cells. We demonstrate that both sera, in fact, have only one antibody (most likely anti-MT2), but have different CYNAP patterns. These observations are discussed with regard to a more complete analysis of antisera that detect gene products of the HLA-DR region.

摘要

通过标准和抗球蛋白增强（AHG）补体依赖细胞毒性（CDC）试验，使用21种靶细胞对两种特征明确的第八届国际研讨会血清8w1090和8w112进行了检测，据说这两种血清分别具有抗DR3和抗DR5活性。我们证明，实际上这两种血清都只有一种抗体（很可能是抗MT2），但具有不同的细胞毒性网络关联模式（CYNAP模式）。针对检测HLA - DR区域基因产物的抗血清进行更全面分析，对这些观察结果进行了讨论。