Fairshter R D, Vaziri N D, Dearden L C, Malott K, Caserio M
Toxicol Appl Pharmacol. 1984 Jun 15;74(1):150-4. doi: 10.1016/0041-008x(84)90281-3.
We evaluated the utility of dimethylthiourea ( DMTU ), a hydroxyl radical scavenger, as potential therapy for paraquat poisoning. Seventy-five male Sprague-Dawley rats were divided into four groups ( DMTU -paraquat, paraquat, DMTU , control) and studied for up to 10 days. Clinical observations (dyspnea, weakness), mortality, hepatic and renal function tests, body weights, and histologic studies were performed. There was no mortality in the DMTU and control groups although various histologic and biochemical studies suggested that DMTU may be both hepatotoxic and nephrotoxic. In contrast, 74% of DMTU -paraquat rats and 39% of paraquat rats died (p less than 0.01). In addition, toxicity was clearly earlier in the DMTU -paraquat group than in the paraquat group. Hence, rather than being protective, treatment with dimethylthiourea was associated with increased mortality in paraquat-poisoned rats.
我们评估了羟基自由基清除剂二甲基硫脲（DMTU）作为百草枯中毒潜在治疗方法的效用。将75只雄性斯普拉格-道利大鼠分为四组（DMTU-百草枯组、百草枯组、DMTU组、对照组），并进行长达10天的研究。进行了临床观察（呼吸困难、虚弱）、死亡率、肝肾功能测试、体重及组织学研究。DMTU组和对照组没有死亡，尽管各种组织学和生化研究表明DMTU可能具有肝毒性和肾毒性。相比之下，74%的DMTU-百草枯组大鼠和39%的百草枯组大鼠死亡（p<0.01）。此外，DMTU-百草枯组的毒性明显早于百草枯组。因此，二甲基硫脲治疗非但具有保护作用，反而与百草枯中毒大鼠死亡率增加有关。
