Aratan-Spire S, Wolf B, Czernichow P
Acta Endocrinol (Copenh). 1984 May;106(1):102-8. doi: 10.1530/acta.0.1060102.
Thyrotrophin-releasing hormone (TRH), like several other neuropeptides, has been detected in the gastro-intestinal tract of adult rats. More recently, elevated concentrations of TRH have been found in the neonatal rat pancreas. This study was undertaken to evaluate pancreatic TRH degrading activity (TRH-DA) in infant rats from birth until adult life. Pancreatic TRH of age-matched rats was also measured by radioimmunoassay. TRH-DA was present in normal adult rat pancreas; though absent at birth and in the early postnatal period up to day 7, this activity was detected during the remainder of the developmental period. TRH content (pg +/- SEM per pancreas) was 1139 +/- 88 on day 1, reached a peak value of 7360 +/- 758 at day 2 and then decreased steadily to adult level. TRH-DA has been found to be present at birth in hypothalamus and liver but not in plasma. The developmental patterns of TRH-DA in plasma and in pancreas were parallel and seem to be thyroid hormone dependent. The absence of TRH-DA in the neonatal pancreas may also be related to the high TRH concentrations detected in this organ during the neonatal period.
促甲状腺激素释放激素（TRH）与其他几种神经肽一样，已在成年大鼠的胃肠道中被检测到。最近，在新生大鼠胰腺中发现TRH浓度升高。本研究旨在评估从出生到成年期幼鼠胰腺中TRH降解活性（TRH-DA）。还通过放射免疫测定法测量了年龄匹配大鼠的胰腺TRH。TRH-DA存在于正常成年大鼠胰腺中；虽然在出生时和出生后早期直至第7天不存在，但在发育阶段的其余时间检测到了这种活性。第1天时胰腺TRH含量（每胰腺pg±SEM）为1139±88，在第2天达到峰值7360±758，然后稳步下降至成年水平。已发现TRH-DA在出生时存在于下丘脑和肝脏中，但不存在于血浆中。血浆和胰腺中TRH-DA的发育模式是平行的，似乎依赖于甲状腺激素。新生胰腺中TRH-DA的缺失也可能与新生儿期该器官中检测到的高TRH浓度有关。
